Investigating early changes in colon adenomas that may lead to colorectal cancer
Official title: Spatially Informed Malignancy Signatures for Colon Adenomas
Funded at Fred Hutchinson Cancer Center · NIH-11074926 · Data updated 2026-11-12
This study is looking at early signs of colon problems, called adenomas, that can lead to colorectal cancer, and it aims to find out what changes in the body might help us catch these issues early and prevent cancer from developing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 20, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $178,226 |
| NIH project number | 3U54CA274374-03S3 |
| Project ID | NIH-11074926 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with diagnosed colon adenomas or those at high risk for developing colorectal cancer.
✕Less likely to help
Patients who do not have colon adenomas or are not at risk for colorectal cancer may not benefit from this research.
What this research studies
This research focuses on understanding the early lesions in the colon, specifically colon adenomas, which can progress to colorectal cancer (CRC). By examining the biological markers and mechanisms involved in the formation and progression of these precancerous lesions, the study aims to identify factors that contribute to cancer development. The research will analyze DNA alterations, aberrant methylation patterns, and other biological changes in the colon tissue of affected individuals. This approach may help in developing strategies for early detection and prevention of CRC.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and prevention of colorectal cancer.
How similar studies have gone: Previous research has shown promising results in understanding the biological mechanisms of colorectal cancer, indicating that this approach may yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Grady, William Mallory — Fred Hutchinson Cancer Center
- Study coordinator: Grady, William Mallory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.