How faulty DNA repair in B cells can lead to blood cancers
Aberrant V(D)J recombination in B cells initiates lymphoid malignancy
This study is looking at how certain changes in DNA can lead to blood cancers in B cells, and it's for patients who want to understand more about their condition and how new treatments might be developed to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11034125 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosomal translocations in B cells, which are often linked to blood cancers. It focuses on understanding how DNA double-strand breaks during a process called V(D)J recombination can lead to these harmful genetic changes. By analyzing data from over 2,000 patients, the study aims to identify specific regions in the DNA that are prone to these breaks and the factors that contribute to their formation. This could help in developing targeted therapies for patients with B cell malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with B cell malignancies or those at high risk for developing such conditions.
Not a fit: Patients with non-B cell cancers or those without any lymphoid malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating blood cancers by targeting the underlying genetic mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding genetic mechanisms in blood cancers, making this approach both relevant and potentially impactful.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Pannunzio, Nicholas — University of California-Irvine
- Study coordinator: Pannunzio, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.