Condition

Malignant Neoplasm clinical trials and research

• 43Clinical trials
• 39Countries

Newest Malignant Neoplasm clinical trials

All recruiting trials (43)

• MK-2010 with Sac-TMT in advanced solid tumors

  This study tests MK-2010 combined with sacituzumab tirumotecan (sac-TMT) to see if it can help people with advanced solid tumors.

  Recruiting at 4 sites Phase 2 Merck Sharp & Dohme LLC · San Antonio, Texas and 3 other locations · NCT07785609

• Belzutifan in adolescents with solid tumors

  This study tests belzutifan in teenagers whose solid tumors can't be removed by surgery or have spread.

  Recruiting at 10 sites Phase 2 Merck Sharp & Dohme LLC · Iowa City, Iowa and 9 other locations · NCT07700758

• Ifinatamab Deruxtecan in kids with relapsed or refractory solid cancers

  This study tests whether I-DXd can help children whose solid tumors have come back or not responded to previous treatments.

  Recruiting at 35 sites Phase 1/2 Merck Sharp & Dohme LLC · Los Angeles, California and 34 other locations · NCT07630974

• MK-4884 safety in advanced solid tumors

  This early-phase study tests different doses of MK-4884 to see if it is safe and tolerable for adults with certain advanced solid cancers.

  Recruiting at 10 sites Phase 1 Merck Sharp & Dohme LLC · St Louis, Missouri and 9 other locations · NCT07600749

• PET scan targeting CDH3 for lung tumors

  This will test whether a new PET imaging agent called 68Ga-TOI-1 that targets CDH3 can better detect and stage lung tumors and help tell malignant from benign pulmonary nodules in adults with suspected or confirmed non-small cell lung cancer.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07487883

• Dabrafenib and trametinib for rare cancers with BRAF V600 mutations

  This arm tests whether dabrafenib and trametinib can help adults, children, and teens with cancers that have a BRAF V600 mutation.

  Recruiting at 15 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT07440290

• Pembrolizumab treatment for Japanese children with solid tumors or lymphomas and Japanese adults with Merkel cell carcinoma

  This study will try pembrolizumab in Japanese children with solid tumors or lymphomas and in Japanese adults with Merkel cell carcinoma to learn about safety, how the drug moves through the body, and whether tumors shrink.

  Recruiting at 7 sites Phase 1/2 Merck Sharp & Dohme LLC · Nagoya, Aichi-ken and 6 other locations · NCT07302347

• Pembrolizumab plus MK-1084 for NSCLC with KRAS G12C mutation

  This trial tests whether adding the targeted drug MK-1084 to pembrolizumab helps people with advanced non‑small cell lung cancer that has a KRAS G12C mutation.

  Recruiting at 39 sites Phase 2 Merck Sharp & Dohme LLC · Clermont, Florida and 39 other locations · NCT07252739

• MK-4716 for certain advanced solid tumors

  This trial will test whether the oral drug MK-4716, given alone or with pembrolizumab or cetuximab, is safe and tolerable for people with advanced or metastatic solid tumors that have KRAS gene changes.

  Recruiting at 21 sites Phase 1 Merck Sharp & Dohme LLC · New Brunswick, New Jersey and 20 other locations · NCT07247110

• Multi-omics early-warning system to detect organ damage during cancer immunotherapy

  This project will try to use multi-omics data and routine clinical measurements from people receiving immune checkpoint inhibitors to build an early-warning system that flags organ damage.

  Recruiting Hebei Medical University Fourth Hospital · Shijiazhuang, Hebei · NCT07131007

• Capmatinib treatment for adults with cancers having MET gene changes

  This study is testing if capmatinib, a drug for lung cancer, can help adults with different types of cancers that have changes in the MET gene.

  Recruiting at 16 sites Phase 2/3 Cancer Research UK · Belfast and 16 other locations · NCT06988475

• MK-5684 for breast, ovarian, and endometrial cancer

  This trial will test whether MK-5684 helps people with certain breast, ovarian, or endometrial cancers live longer without the disease growing or spreading.

  Recruiting at 60 sites Phase 2 Merck Sharp & Dohme LLC · Anchorage, Alaska and 59 other locations · NCT06979596

• Patritumab deruxtecan for children with relapsed or refractory hepatoblastoma or rhabdomyosarcoma

  This trial tests an antibody-drug conjugate called HER3-DXd (patritumab deruxtecan) to see if it is safe and can shrink relapsed or treatment-resistant hepatoblastoma or rhabdomyosarcoma in children.

  Recruiting at 64 sites Phase 1/2 Merck Sharp & Dohme LLC · Los Angeles, California and 63 other locations · NCT06941272

• Evaluating MK-3120 for advanced solid tumors

  This study is testing a new treatment called MK-3120 to see if it can help people with advanced solid tumors that can't be removed by surgery.

  Recruiting at 28 sites Phase 1/2 Merck Sharp & Dohme LLC · Birmingham, Alabama and 48 other locations · NCT06818643

• Evaluating a new imaging agent for cancer detection

  This study is testing a new imaging agent for cancer called 18F-FAPI-Biotin to see if it can help doctors find tumors better than current imaging methods.

  Recruiting Early Phase 1 First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT06734572

• First use of 68Ga-NI-FAPI PET/CT for cancer diagnosis

  This study is testing a new imaging agent called 68Ga-NI-FAPI to see if it can help doctors better spot different types of cancer using PET/CT scans.

  Recruiting Early Phase 1 First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT06688305

• Study of a new radiotracer for cancer imaging

  This study is testing a new imaging agent for cancer to see how well it helps doctors spot tumors in patients with different types of cancer.

  Recruiting Early Phase 1 First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT06688188

• Evaluating a new radiotracer for cancer imaging

  This study is testing a new imaging agent for cancer that helps doctors see tumors better by focusing on a specific protein found in cancer cells.

  Recruiting Early Phase 1 First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT06438250

• Treatment for advanced solid tumors with KRAS G12D mutation

  This study is testing a new drug called TSN1611 to see if it can safely help people with advanced solid tumors that have a specific KRAS G12D mutation.

  Recruiting at 19 sites Phase 1/2 Tyligand Pharmaceuticals (Suzhou) Limited · Houston, Texas and 18 other locations · NCT06385925

• Engaging American Indians in cancer genome sequencing

  This study is trying to find better ways to involve American Indians in Southwestern Tribal Nations in cancer research by looking at their genetic information to help improve cancer prevention and treatment.

  Recruiting New Mexico Cancer Research Alliance · Albuquerque, New Mexico · NCT06207864

• Monoclonal antibody treatment for advanced solid tumors

  This study is testing a new antibody treatment for people with advanced solid tumors to see if it is safe and effective on its own or when combined with another cancer drug.

  Recruiting at 4 sites Phase 1/2 OncoResponse, Inc. · Austin, Texas and 3 other locations · NCT06090266

• Using NV-001 vaccine to treat advanced solid tumors

  This study is testing a new vaccine made from patients' own tumor tissues to see if it can safely help people with advanced solid tumors who haven't had success with other treatments.

  Recruiting Phase 1 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06051760

• Oral treatment with NBM-BMX for patients with solid tumors or glioblastoma

  This study is testing a new oral medication called NBM-BMX to see if it can help people with advanced solid tumors or newly diagnosed glioblastoma, either on its own or alongside standard treatments.

  Recruiting at 3 sites Phase 1/2 Novelwise Pharmaceutical Corporation · Kaohsiung City and 3 other locations · NCT06012695

• Treatment of advanced solid tumors with PM8002

  This study is testing a new treatment called PM8002 to see if it can help adults with advanced solid tumors by targeting specific proteins that may help fight their cancer.

  Recruiting at 48 sites Phase 1/2 BioNTech SE · Baoji and 47 other locations · NCT05918445

• Targeting Integrin αvβ6 for PET Imaging in Cancer

  This study is testing a new imaging tool to see if it can help doctors better diagnose and stage certain cancers, like lung and breast cancer, by using a special scan that targets a specific protein found in tumors.

  Recruiting Zhongnan Hospital · Wuhan, Hubei · NCT05835570

• Entrectinib treatment for patients with ROS1-positive cancers

  This study is testing if the drug entrectinib can help people with different types of cancers that have a ROS1 gene fusion, including adults and kids, to see if it works better than what’s currently available.

  Recruiting at 24 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05770544

• Using atezolizumab to treat cancers with high mutation rates or specific genetic deficiencies

  This study is testing if atezolizumab can help treat adults and kids with certain types of cancers that have a lot of genetic changes or specific genetic issues.

  Recruiting at 23 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05770102

• Alectinib treatment for ALK-positive cancers in adults and children

  This study is testing if alectinib, a drug for lung cancer, can help treat different types of ALK-positive cancers in both adults and children.

  Recruiting at 24 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05770037

• Home-based care for advanced cancer patients

  This study is testing if home-based care can help advanced cancer patients avoid unexpected hospital visits over six months.

  Recruiting at 6 sites Seoul National University Hospital · Goyang-si, Gyeonggi-do and 5 other locations · NCT05636384

• Using 68Ga-FAPI PET/CT to visualize malignant tumors

  This study is testing a new imaging method using a special agent to see if it can help doctors better spot and understand malignant tumors, especially in gastrointestinal cancers.

  Recruiting Zhongnan Hospital · Wuhan, Hubei · NCT05034146

• Using ICG dye to improve tumor margin identification during surgery

  This study tests whether using a special dye during surgery can help doctors see tumor edges better and improve outcomes for patients with bone or soft tissue tumors.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT04752137

• Using FAPI-PET imaging to detect tumors

  This study is testing if a new type of imaging called FAPI-PET can help doctors find tumors better in patients who are being checked for cancer.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT04571086

• Using an iPhone app to help adolescents and young adults lose weight after stem cell transplant

  This study is testing whether an iPhone app and coaching can help young people lose weight after they've had a stem cell transplant.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT04453072

• Using patient-derived cancer models to address health disparities in cancer treatment

  This study is trying to create and test cancer models from patients, especially those from minority backgrounds, to see how we can improve cancer treatments for bladder, gastric, liver, and lung cancers.

  Recruiting at 2 sites University of California, Davis · Orange, California and 1 other locations · NCT04410302

• Genetic studies of cancer patients and their families

  This study looks at how genetics and family history might affect cancer risk in patients and their relatives to better understand the disease.

  Recruiting at 41 sites City of Hope Medical Center · Phoenix, Arizona and 41 other locations · NCT04185935

• Collecting immune system samples from cancer patients, blood disorder patients, and healthy volunteers

  This study is collecting blood and tissue samples from cancer patients, blood disorder patients, and healthy volunteers to see how their immune systems respond to different treatments.

  Recruiting University of Southern California · Los Angeles, California · NCT03207854

• Collecting cancer-related data and samples for personalized medicine

  This study is collecting blood, tissue, and other samples from cancer patients and those at risk to see how this information can help create more personalized treatments for cancer.

  Recruiting University of Southern California · Los Angeles, California · NCT02970045

• Genomic analysis of blood and tissue samples from cancer patients

  This study is testing whether analyzing blood and tissue samples from cancer patients can help find specific genetic changes that might improve treatment options, especially for rare cancers.

  Recruiting at 2 sites Rutgers, The State University of New Jersey · Brick, New Jersey and 10 other locations · NCT02688517

• Using donor T cells to treat cancer patients with BK and JC viruses

  This study is testing if infusions of special immune cells from donors can help cancer patients with BK or JC virus infections feel better and fight their illness.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT02479698

• Gathering health information for younger cancer patients

  This study is gathering health information from younger cancer patients to help improve treatments and support future research.

  Recruiting at 253 sites Children's Oncology Group · Birmingham, Alabama and 278 other locations · NCT02402244

• Analyzing genetic mutations in cancer patients' blood and saliva

  This study is testing whether looking at genetic changes in blood and saliva from cancer patients can help us understand their cancer risk and how well they respond to treatments.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT02280161

• Examining the link between physical activity and survival in advanced cancer patients

  This study is testing how physical activity affects survival and overall health in people with advanced cancer by using wearable devices to track their activity levels.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT01365169

• New assessment system for measuring symptoms in cancer patients

  This study is testing a new way to measure symptoms and their impact on quality of life for cancer patients to see if it can help improve their care.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT00505245

Related topics

Quick answers

How many Malignant Neoplasm clinical trials are recruiting right now?

43, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 39 countries. The most sites are in United States (24 trials), China (13 trials), United Kingdom (7 trials), South Korea (7 trials), Spain (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 8, Phase 2: 6, Phase 2/3: 5, Early Phase 1: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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