Investigating how certain genetic factors influence neuroblastoma in children
Targetable epigenetic modifiers that promote neuroblastoma malignancy and plasticity
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11050940
This study is looking at how certain genes make high-risk neuroblastoma, a tough childhood cancer, harder to treat, with the hope of finding better therapies for kids who need more options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11050940 on ClinicalTrials.gov |
What this research studies
This research focuses on neuroblastoma, a serious cancer affecting the sympathetic nervous system in children. It aims to identify the genetic vulnerabilities that contribute to the malignancy and treatment resistance of high-risk neuroblastoma. By utilizing advanced techniques like transcriptomics and CRISPR screening, the study seeks to understand how specific transcription factors and epigenetic modifiers are involved in the cancer's development and progression. The goal is to develop more effective therapies for patients who currently have limited treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk neuroblastoma, particularly those who have not responded well to existing treatments.
Not a fit: Patients with low-risk neuroblastoma or those whose cancer is not MYC-driven may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies that improve survival rates for children with high-risk neuroblastoma.
How similar studies have performed: Previous research has shown promise in targeting epigenetic modifiers in cancer treatment, indicating that this approach could be effective.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, JUN — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: YANG, JUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.