Condition

Carcinoma clinical trials and research

• 25Clinical trials
• 469NIH research projects
• 18Countries

Newest Carcinoma clinical trials

All recruiting trials (25)

• TriAdeno and N-803 vaccine in early prostate cancer on active surveillance

  A vaccine combo called TriAdeno plus the N-803 drug is being tested to see if it can help slow or stop growth in men with early-stage, low- to intermediate-risk prostate cancer who are being watched rather than treated right away.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07574541

• PF-08634404 Alone or with chemotherapy in early-stage or locally advanced NSCLC

  This study tests PF-08634404 by itself or with chemotherapy in adults with early-stage or locally advanced non-small cell lung cancer that may be surgically removable or were candidates for additional therapy after initial treatment.

  Recruiting at 28 sites Phase 2 Pfizer · Huntsville, Alabama and 36 other locations · NCT07489066

• Validate a French Nasal Reconstruction FACE-Q quality-of-life questionnaire

  This project tests a French version of the Nasal Reconstruction FACE-Q questionnaire with adults who had nasal reconstruction or prosthetic rehabilitation after nasal skin cancer.

  Recruiting at 4 sites Hôpital NOVO · Caen and 8 other locations · NCT07257094

• Carbon ion radiotherapy for liver cancer that returned after TARE

  This trial will try carbon ion radiotherapy to control liver tumors in people whose hepatocellular carcinoma persisted or came back after TARE.

  Recruiting Yonsei University · Seoul · NCT07252323

• Carbon ion radiotherapy plus atezolizumab and bevacizumab for advanced hepatocellular carcinoma

  This trial will try adding carbon ion radiotherapy to standard atezolizumab‑bevacizumab treatment for adults with advanced hepatocellular carcinoma to see if it controls tumors better and improves survival.

  Recruiting Phase 2 Yonsei University · Seoul · NCT07246668

• Evaluating Pucotenlimab for treating pediatric lymphoepithelioma-like carcinoma

  This study is testing a new treatment combining pucotenlimab with chemotherapy to see if it helps children and teenagers with a rare type of cancer called lymphoepithelioma-like carcinoma.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06969534

• Using vorolanib for treating advanced kidney cancer

  This study is testing if the drug vorolanib can help people with advanced kidney cancer live longer when used as a second treatment option.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT06676527

• Using circulating tumor DNA to tailor post-surgery treatment for HPV-related throat cancer

  This study is testing if adjusting cancer treatment based on blood tests for HPV DNA can help people with throat cancer after surgery feel better and improve their outcomes.

  Recruiting at 4 sites Phase 2 Cedars-Sinai Medical Center · Beverly Hills, California and 3 other locations · NCT06445114

• Genetic testing to personalize belinostat treatment for high-grade neuroendocrine carcinomas

  This study is testing if genetic testing can help find the right dose of the cancer drug belinostat for people with high-grade neuroendocrine carcinomas to improve treatment results and reduce side effects.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06406465

• Predicting lymph node metastasis in non-small cell lung cancer using blood tests and imaging

  This study is testing if blood tests and imaging can help predict if non-small cell lung cancer has spread to lymph nodes in patients before surgery.

  Recruiting Shanghai Chest Hospital · Shanghai · NCT06358222

• Biobank for pancreatic adenocarcinoma research

  This study is collecting samples and information from people with pancreatic cancer to help find better ways to diagnose and treat the disease.

  Recruiting University Hospital, Toulouse · Béthune and 7 other locations · NCT06128343

• Combination treatment for HER2-positive upper tract urothelial carcinoma after surgery

  This study is testing a new combination of targeted therapy and immune treatment to see if it helps prevent cancer from coming back in patients with HER2-positive upper tract urothelial carcinoma after surgery.

  Recruiting Phase 2 Jinling Hospital, China · Nanjing, Jiangsu · NCT05917158

• Monitoring kidney cancer using blood tests for DNA changes

  This study is testing if blood tests that look for DNA changes can help track kidney cancer in patients before and after surgery.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT05917106

• Using targeted radiation therapy for small liver cancer recurrence

  This study is testing whether a special type of targeted radiation therapy can help people with small liver cancer that has come back after surgery or other treatments.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05596630

• Treatment with STAR0602 for advanced solid tumors

  This study is testing a new treatment called STAR0602 to see if it can help people with advanced solid tumors by looking at how safe it is and how well it works.

  Recruiting at 16 sites Phase 1/2 Marengo Therapeutics, Inc. · Sacramento, California and 18 other locations · NCT05592626

• Combining Cabozantinib and Dostarlimab for Recurrent Gynecologic Carcinosarcoma

  This study is testing if combining two drugs, Cabozantinib and Dostarlimab, can help people with recurrent gynecologic carcinosarcoma who have already had chemotherapy.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT05559879

• Combination treatment for ctDNA positive gastric cancer

  This study is testing a new combination treatment for patients with a specific type of stomach cancer to see if it works better than the usual treatment.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT05494060

• Evaluating oral hedgehog inhibitors for treating basal cell carcinoma in the Netherlands

  This study is testing if two oral medications, vismodegib and sonidegib, can help people with advanced basal cell carcinoma or Gorlin syndrome feel better and improve their condition.

  Recruiting at 7 sites Maastricht University Medical Center · Nijmegen, Gelderland and 7 other locations · NCT05463757

• Evaluating NRC-2694-A with Paclitaxel for Head and Neck Cancer After Immune Therapy

  This study is testing a new oral medication called NRC-2694-A combined with paclitaxel to see if it can help people with head and neck cancer who haven't responded to other immune therapies.

  Recruiting Phase 2 NATCO Pharma Ltd. · Fullerton, California and 12 other locations · NCT05283226

• National registry for ovarian and endometrial cancer patients

  This study is setting up a national registry to track information about patients with advanced ovarian and endometrial cancer in Germany to see how they respond to different treatments over time.

  Recruiting iOMEDICO AG · Multiple Locations · NCT05129969

• B7-H3 CAR T-cell therapy for pediatric solid tumors

  This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04897321

• Evaluating the safety and effectiveness of ST-067 in treating various solid tumors

  This study is testing a new treatment called ST-067 to see if it can help people with tough-to-treat solid tumors feel better and improve their health.

  Recruiting at 6 sites Phase 1/2 Simcha IL-18, Inc. · Scottsdale, Arizona and 5 other locations · NCT04787042

• Comparing Propofol and Sevoflurane for Children's Tumor Surgery

  This study is testing whether two types of anesthesia, propofol and sevoflurane, can affect the health and recovery of children having surgery for tumors.

  Recruiting Phase 4 Hong Kong Children's Hospital · Hong Kong · NCT04475705

• AI-based precision oncology clinical trial matching and registry

  This study is testing whether an AI tool can help match cancer patients with the right clinical trials based on their specific cancer details to see if it improves their chances of getting into trials and their overall outcomes.

  Recruiting at 68 sites Massive Bio, Inc. · Birmingham, Alabama and 67 other locations · NCT03452774

• Improving treatment planning for recurrent colorectal cancer using MRI

  This study is testing a new way to use MRI scans to help doctors plan better treatments for patients with recurrent colorectal cancer.

  Recruiting at 4 sites Imperial College London · Oslo and 3 other locations · NCT02292641

NIH-funded research (newest 40 of 469)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Novel idea: Epstein-Barr virus and eye cancer in people living with HIV in Zimbabwe

  A study explores whether Epstein-Barr virus could cause a type of eye cancer in people living with HIV in Zimbabwe.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11625534

• Glutamine and macrophage behavior in liver cancer

  A funded project at a medical university aims to understand how the liver’s immune cells interact with a specific type of liver cancer by looking at metabolism, especially glutamine and ammonia.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11623910

• Understanding bladder cancer biology to find new biomarkers and therapies

  A study at Tuskegee University will look at the molecules inside high-grade bladder cancer to discover new markers and potential treatment targets.

  NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621784

• Oral cancer recurrence predictor using tumor microbes and gene activity

  This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11591548

• Understanding how bladder cancer starts in Veterans exposed to carcinogens and the role of PPAR-g in early bladder cancer

  A research team is studying how bladder cancer begins and progresses in Veterans exposed to carcinogens, focusing on the PPAR-γ protein and early precancerous changes.

  NIH research VA Medical Center · New York, United States · NIH-11575172

• Adding PSMA PET/CT imaging to liver cancer care for veterans

  This project tests a new PET imaging approach to help diagnose and guide treatment for liver cancer in veterans.

  NIH research Miami VA Health Care System · Miami, United States · NIH-11548307

• Data-driven classification of aggressive tissue traits to predict cancer outcomes in HPV-negative head and neck cancer

  A clinician-science grant uses data science and AI to identify tissue patterns in HPV-negative head and neck cancer that may predict how long patients stay cancer-free.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11505841

• Blood markers to catch early liver cancer in Hispanic people with hepatitis B

  This project will see if a blood test can find liver cancer earlier in Hispanic people who have chronic hepatitis B.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11473605

• Early blood markers to find hepatitis B–related liver cancer in Hispanics

  This project will use immune-related blood markers to find liver cancer earlier in people with chronic hepatitis B, focusing on Hispanic adults.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11473604

• Towards a blood-based test using nanophotonic exosomes to screen and diagnose liver cancer

  A new blood test using tiny particles shed by liver cancer cells aims to screen for hepatocellular carcinoma earlier and more accurately.

  NIH research University of Houston · Houston, United States · NIH-11455308

• Exploring understudied proteins as potential drug targets for adenoid cystic carcinoma

  A small NIH grant is funding a patient-focused look at rare salivary gland cancer to find new proteins that could become targeted treatments.

  NIH research University of Chicago · Chicago, United States · NIH-11453523

• Metabolic imaging to guide targeted therapy for liver cancer

  A clinician-scientist at UPenn is pursuing training to use metabolic imaging to tailor therapy for hepatocellular carcinoma.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11451904

• Targeting PIPKIγi5 to boost immune responses against head and neck cancer

  A study to see if blocking a specific enzyme, PIPKIγi5, can make head and neck cancer more visible to the immune system and more responsive to existing immunotherapies.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11449300

• Targeted approaches for lung squamous cell carcinoma with key gene changes

  A study at a major university is exploring new targets in lung squamous cell carcinoma to help people with this cancer find better treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11449092

• Spatial immune patterns in colorectal adenoma-carcinoma progression

  A long-term study looking at how immune cells in the colon relate to the development of colorectal precancers and cancers in adult participants.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11446834

• Understanding how kidney cancer spreads to bone and how to fight it

  A patient-focused look at how clear cell renal cell carcinoma spreads to bone and how new treatments might help people with advanced disease.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11446651

• Baculovirus-based therapy to treat head and neck cancer with a gentle, minimally invasive approach

  A new, minimally invasive approach using baculovirus-delivered CRISPR gene editing aims to treat head and neck squamous cell carcinoma while aiming to preserve essential tissues.

  NIH research University of Kentucky · Lexington, United States · NIH-11445557

• Reducing bacteria inside oral cancer tumors to boost immune response

  In people with head and neck cancer, this study tests whether lowering bacteria in tumors can help the immune system fight the cancer better.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11439220

• Improve precision medicine for kidney cancer in people of African descent

  A research project will explore why kidney cancer affects people of African ancestry differently and how to use genomics to guide better treatments.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11433340

• Targeting the adenosine pathway to boost immune responses against liver cancer

  Aimed at helping people with hepatocellular carcinoma, this grant explores a drug target in the tumor environment to make immunotherapies work better.

  NIH research University of Texas El Paso · El Paso, United States · NIH-11419913

• Role of metabolic stress in NASH-related liver cancer

  This grant explores how metabolic stress linked to NASH may drive liver cancer and looks for ways to interrupt that process to help patients.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11418957

• Novel look at EBV as a possible cause of eye cancer in people with HIV in Zimbabwe

  A study will explore whether Epstein-Barr virus may contribute to an eye cancer (cSCC) in people living with HIV in Zimbabwe.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11418498

• Genetic ancestry and racial differences in liver cancer risk and survival

  This grant looks at how a person’s genetic background might help explain why some racial groups have higher risk and worse survival from liver cancer.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11417235

• Engineering immunogenic cell death to boost melanoma and kidney cancer therapy

  This grant supports research aimed at making melanoma and kidney cancer cells die in a way that triggers a stronger immune response in patients.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11415156

• Does Epstein-Barr virus cause conjunctival (eye) cancer in people with HIV in Zimbabwe?

  This project looks for a link between the Epstein-Barr virus and conjunctival squamous cell carcinoma in people living with HIV in Zimbabwe.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11414781

• Prognostic test to predict metastasis in clear cell kidney cancer

  A new 12-marker biomarker test for people with clear cell renal cell carcinoma may help doctors predict which patients are at higher risk of metastasis.

  NIH research Lagrange Scientific, LLC · Pewee Valley, United States · NIH-11412572

• BVES protein in colorectal cancer: stopping tumor spread by stabilizing cell junctions

  This grant explores how BVES, a protein at cell junctions, prevents colorectal cancer cells from becoming more aggressive and how restoring BVES could lead to new ways to stop tumor growth.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11412317

• Engineered CAR-T Therapy to Target Liver Cancer

  A new CAR-T cell treatment is being developed for hepatocellular carcinoma to better recognize tumors and resist the immune-suppressing environment.

  NIH research March Biosciences INC · Houston, United States · NIH-11410236

• Hypoxia and metabolism as targets to improve immunotherapy in head and neck cancer

  This grant tests new combinations of metabolic drugs with immunotherapy to help people with head and neck cancer respond better to treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11404946

• CD1530: A promising oral cavity cancer prevention approach using a RAR gamma activator

  A researcher is testing a drug that activates a receptor in the lining of the mouth to help prevent squamous cell cancers before they start or spread.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11403870

• Postoperative ctDNA in Drain Fluid to Detect Remaining Cancer in Head and Neck Cancer

  A patient-friendly test using fluid from surgical drains after head and neck cancer surgery may reveal tiny remaining cancer cells sooner.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11402625

• Defining metabolic targets in kidney cancer for new treatments

  A cancer-focused project is exploring how kidney cancer uses metabolism so doctors can find new, targeted ways to treat it.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11400752

• Targeting HIF2 in kidney cancer: a new approach for clear cell RCC

  A kidney cancer research program tests whether blocking HIF2 can slow or stop tumors in people with clear cell renal cell carcinoma.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11400746

• Diagnose high-grade ovarian cancer precursors and hidden tumors

  This grant aims to improve early detection of ovarian cancer precursors and occult tumors by analyzing cells collected from the fallopian tubes and surrounding areas in high-risk women.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11399029

• Genomic map of cutaneous squamous cell carcinoma and its earliest genetic changes

  This project looks at the genes involved in a common skin cancer (cutaneous squamous cell carcinoma) to understand what mutations drive its growth and how it evolves from benign skin lesions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11398277

• Chromosome 3 Aneuploidy in Squamous Cell Carcinoma and its Impact on Key Cancer Pathways

  This grant studies how losing or gaining parts of chromosome 3 drives squamous cell cancers and alters important cell signaling and growth pathways.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11398272

• Designer cytokine therapy for liver cancer

  A new, targeted cytokine therapy is being studied to shrink liver tumors and help the immune system reach and destroy cancer cells in people with advanced hepatocellular carcinoma.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11395191

• New immune-target approach to help liver cancer patients

  A new grant is exploring how a specific immune cell pathway in liver cancer could be targeted to improve treatment, especially for people with hepatocellular carcinoma.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11395187

• Cooperation of co-amplified genes in liver cancer (HCC)

  This grant funds research to understand how two amplified genes, MYC and TAF2, work together to drive liver cancer and to find better treatment strategies for patients with this disease.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11395185

• Targeted therapies for fatty liver-related liver cancer (ELEVATE)

  A multi-project effort at a major university is exploring new treatment combinations for advanced liver cancer, especially when linked to obesity-related liver disease.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11395180

Related topics

Quick answers

How many Carcinoma clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (10 trials), China (8 trials), France (3 trials), Hong Kong (2 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1/2: 3, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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