Condition

Lumbar Spinal Stenosis clinical trials and research

• 25Clinical trials
• 2NIH research projects
• 11Countries

Newest Lumbar Spinal Stenosis clinical trials

All recruiting trials (25)

• Effect of Irrigation Pressure on Postoperative Complications and Surgical Field Clarity in Unilateral Biportal Endoscopic Spine Surgery

  This study tests whether the height of the irrigation fluid bag and the direction of the surgical cut affect fluid pressure, visibility, and early recovery in adults undergoing unilateral biportal endoscopic spine surgery.

  Recruiting First Affiliated Hospital of Kunming Medical University · Kunming, Yunnan · NCT07837427

• Microdecompression alone vs. decompression with fusion in adjacent segment stenosis

  This trial tests whether a less invasive microdecompression can work as well as adding a fusion extension for people with adjacent segment stenosis after prior lumbar fusion.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07661199

• Comparison of two TLIF procedures for single-level lumbar spinal stenosis

  This trial tests two minimally invasive TLIF procedures (LUSE-TLIF and MIS-TLIF) to see which better helps people with single-level lumbar spinal stenosis who have not improved with non-surgical treatments.

  Recruiting The Third Affiliated Hospital of Southern Medical University · Guangzhou, Guangdong · NCT07588555

• Opioid-free versus opioid-based anesthesia for elective lumbar spine surgery

  This test compares opioid-free multimodal anesthesia (with or without an erector spinae plane block) against opioid-containing anesthesia in adults having elective lumbar spine surgery to see which controls pain better and reduces opioid need in the first 48 hours after surgery.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07489001

• Prevalence of PAD in Patients With Surgically Treated Lumbar Spinal Stenosis

  This study tests how common peripheral artery disease is in people who have lumbar spinal stenosis and are being considered for, or have had, surgery.

  Recruiting Rennes University Hospital · Lille and 2 other locations · NCT07469020

• Decompressive laminectomy alone versus laminectomy with transpedicular screw fixation for lumbar spinal stenosis

  Adults age 30–60 with multilevel lumbar spinal stenosis who haven't improved after six weeks of non-surgical care will be randomly assigned to decompressive laminectomy alone or to laminectomy plus transpedicular screw fixation to see which option relieves pain, improves function, and gives better spinal stability.

  Recruiting Early Phase 1 Punjab Health Care Commission · Lahore, Punjab Province · NCT07281625

• Dural pulsation in people with lumbar spinal stenosis

  This study will see if the presence of dural pulsation on MRI is linked to symptoms and imaging findings in people with lumbar spinal stenosis.

  Recruiting Marmara University · Pendik, Istanbul · NCT07233798

• Pressure-guided limited bone removal versus standard laminectomy for symptomatic lumbar spinal stenosis

  This test will see if using epidural pressure to guide a smaller bone removal works as well as standard open laminectomy for people with symptomatic lumbar spinal stenosis.

  Recruiting Universidad Complutense de Madrid · Madrid · NCT07026305

• Assessing walking patterns in patients with lumbar spinal stenosis

  This study looks at how walking patterns change in people aged 20-65 who have had surgery for lumbar spinal stenosis to better understand their mobility after recovery.

  Recruiting Pamukkale University · Denizli · NCT06750055

• Comparing three surgical techniques for treating lumbar spinal stenosis

  This study is testing which of three different surgical methods works best for treating lumbar spinal stenosis in patients.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT06719037

• Impact of degenerative spondylolisthesis on outcomes of endoscopic surgery for spinal stenosis

  This study is testing how degenerative spondylolisthesis affects recovery after endoscopic surgery for lumbar spinal stenosis in patients aged 50-80 who haven't found relief from other treatments.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT06394089

• Motion and recovery after Minuteman G5 lumbar fusion

  This trial will test whether the Minuteman G5 fusion plate plus bone graft improves walking, balance, pain, and quality of life for adults with degenerative lumbar spine disease and neurogenic claudication.

  Recruiting at 6 sites Spinal Simplicity LLC · Newnan, Georgia and 6 other locations · NCT06355791

• Testing a new medication for low back and leg pain relief.

  This study is testing a new medication to see if it can help people aged 18 to 80 with back and leg pain feel better.

  Recruiting at 8 sites Phase 4 Primus Pharmaceuticals · Auburn, Alabama and 23 other locations · NCT06157177

• Non-invasive therapy for older veterans with spinal stenosis

  This study is testing a non-invasive therapy for older veterans with spinal stenosis to see if it can help them walk better and feel less pain without needing surgery.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT06089746

• Investigating Balance in Elderly Patients with Lumbar Spinal Stenosis

  This study is testing how decompressive surgery affects balance in older adults with lumbar spinal stenosis before and after the procedure.

  Recruiting Region Zealand · Køge and 1 other locations · NCT06075862

• Investigating activity levels in elderly patients with lumbar spinal stenosis after surgery

  This study looks at how surgery for lumbar spinal stenosis affects the activity levels of elderly patients aged 65 and older before and after the procedure over two years.

  Recruiting Region Zealand · Køge and 1 other locations · NCT06057428

• Identifying cardiac amyloidosis in older adults with lumbar spinal stenosis

  This study is trying to find out if older adults who have had surgery for lumbar spinal stenosis also have a heart condition called transthyretin cardiac amyloidosis by looking at their spinal tissue and using advanced technology.

  Recruiting at 5 sites Columbia University · Beverly Hills, California and 5 other locations · NCT06034405

• Evaluation of a new device for treating low back pain

  This study is testing a new device to see if it can safely help people with chronic low back pain from degenerative disc disease feel better when other treatments haven't worked.

  Recruiting at 9 sites Pacific Research Institute · Santa Rosa, California and 9 other locations · NCT05504499

• Fusion versus decompression alone for single-level lumbar stenosis

  This trial will test whether decompression surgery without added fusion works as well as decompression plus fusion for adults aged 45–75 with single-level lumbar spinal stenosis.

  Recruiting at 2 sites Sklifosovsky Institute of Emergency Care · Moscow, Moscow and 1 other locations · NCT05273879

• Using steroids during lumbar surgery to reduce pain and opioid use

  This study tests if using steroids during back surgery can help reduce pain and the need for opioids in patients recovering from the procedure.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT05058287

• Using regional anesthesia to reduce opioid use in spine surgery

  This study is testing if a special pain management technique can help people having spine surgery use less opioid medication after their operation.

  Recruiting Phase 4 Rush University Medical Center · Chicago, Illinois · NCT05029726

• Comparing local and MAC anesthesia for lumbar decompression surgery

  This study tests whether using local anesthesia with monitored care is as safe and effective as general anesthesia for patients having lumbar decompression surgery for spinal stenosis.

  Recruiting at 2 sites Early Phase 1 Stanford University · Redwood City, California and 1 other locations · NCT04992572

• Predicting success of epidural injections for sciatica treatment

  This study is trying to find out which factors can help predict how well epidural injections will work for people with sciatica caused by a herniated disc or spinal stenosis.

  Recruiting Leiden University Medical Center · Haarlem · NCT04540068

• Impact of muscle degeneration on chronic low back pain after surgery

  This study looks at how muscle loss affects ongoing back pain in people who have surgery for spine problems, to help improve recovery and predict results.

  Recruiting Hospital Israelita Albert Einstein · São Paulo, São Paulo · NCT04273828

• Comparing MILD procedure outcomes for lumbar spinal stenosis patients

  This study looks at how well the MILD procedure works for people with lumbar spinal stenosis compared to another treatment, to see which one leads to better outcomes and fewer complications.

  Recruiting at 2389 sites Stryker Instruments · Athens, Alabama and 2393 other locations · NCT03072927

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Combining hands-on therapy, exercise, and intramuscular electroacupuncture for walking pain from lumbar spinal stenosis

  This project tests whether adding intramuscular electroacupuncture and periodic booster sessions to manual therapy plus exercise can give better and longer-lasting relief for people with lumbar spinal stenosis who have walking-related leg pain (neurogenic claudication).

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11160739

• Improving treatment for lumbar spinal stenosis and related walking difficulties

  This study is looking at how combining hands-on therapy and exercise, possibly with a special type of acupuncture, can help people with back pain and leg cramps feel better and walk easier.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10904004

Related topics

Quick answers

How many Lumbar Spinal Stenosis clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (9 trials), China (4 trials), Turkey (Türkiye) (3 trials), Denmark (2 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Early Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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