Impact of degenerative spondylolisthesis on outcomes of endoscopic surgery for spinal stenosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate how degenerative spondylolisthesis affects the clinical outcomes of unilateral biportal endoscopy in patients with lumbar spinal stenosis. It will involve a single-center, prospective cohort design, focusing on patients aged 50-80 who have been diagnosed with lumbar spinal stenosis affecting 1-2 vertebral levels and have not responded to conservative treatment. The study will assess the effectiveness of the surgical intervention in this specific patient population, providing valuable insights into their recovery and overall outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range: 50-80 years
* Diagnosis of LSS affecting 1-2 vertebral levels
* Predominant manifestation of neurogenic intermittent claudication, with ineffective conservative treatment for at least 3 months
* Presence of lumbar DS of less than grade II and absence of spine instability
* Willingness to participate in the study and complete follow-up assessments.

Exclusion Criteria:

* Diagnosis of isthmic lumbar spondylolisthesis or lumbar DS of grade ≥II
* Evidence of instability at the affected vertebral level (intervertebral angle change \> 15° and/or vertebral translation ≥ 4.5 mm in standing flexion-extension radiographs of the lumbar spine)
* History of prior surgery at the affected vertebral level
* Presence of scoliosis with a Cobb angle \>20º
* Presence of other conditions affecting the lumbar spine (infection, tumor, fracture, neurological diseases, and others)
* Medical disorders that preclude surgical tolerance
* Participation in other clinical research projects related to the treatment of lumbar spinal stenosis.

Where it's running

• Beijing Friendship Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Xiang Li
• Email: muzixiangxin2022@163.com
• Phone: +86 10 6313 9155

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.