Condition

Graft Versus Host Disease clinical trials and research

• 28Clinical trials
• 35NIH research projects
• 13Countries

Newest Graft Versus Host Disease clinical trials

All recruiting trials (28)

• Anti-CD25 antibody to prevent acute GVHD after haploidentical stem cell transplant

  This study tests whether an anti-CD25 antibody can better prevent acute graft-versus-host disease after haploidentical hematopoietic stem cell transplantation compared with the usual methotrexate-based approach.

  Recruiting Phase 3 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07689630

• Ruxolitinib for Graft-Versus-Host Disease in Clinical Practice

  This study tests how well Jakavi (ruxolitinib) works and how safe it is for people with acute or chronic GVHD being treated in real-world medical settings.

  Recruiting Novartis · Tokyo · NCT07594587

• Moxibustion with second-line treatment for steroid-refractory acute graft-versus-host disease after transplant

  This study will test whether adding moxibustion to standard second-line drug therapy helps people aged 14–65 with steroid-refractory gastrointestinal acute GVHD after an allogeneic stem cell transplant.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07572669

• Cord blood transplant for children and young adults with blood cancers.

  This study will test whether a cord blood transplant given as a first or second transplant can help children and young adults with leukemia, myelodysplasia, or lymphoma who lack a matched donor.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT07566377

• Ruxolitinib maintenance after stem cell transplant for T‑cell lymphoma

  This phase II trial tests whether taking ruxolitinib after a stem cell transplant can lower the chance of relapse and graft‑versus‑host disease for people treated for T‑cell lymphoma.

  Recruiting at 2 sites Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio and 1 other locations · NCT07356245

• Optimizing and Unifying Management of HSCT in Pediatric ALL

  This trial tests a harmonized HSCT approach for children and young people with ALL, aiming to reduce transplant-related risks and improve long-term outcomes.

  Recruiting at 2 sites Phase 2/3 Bambino Gesù Hospital and Research Institute · Vienna and 8 other locations · NCT07297914

• BPC2001 to prevent acute graft-versus-host disease after haploidentical stem cell transplant

  This trial tests whether six weekly doses of BPC2001 given with standard care can prevent acute graft-versus-host disease in adults having haploidentical stem cell transplants.

  Recruiting at 2 sites Phase 2 BioPhoenix Co., Ltd. · Beijing, Beijing Municipality and 1 other locations · NCT07246031

• Immune Cells in Blood and Tissues After Allogeneic Transplant and Chronic GVHD

  This study tests whether immune cells in blood and other samples differ between people who develop chronic GVHD after an allogeneic transplant and those who don’t.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07235501

• Belumosudil to prevent graft-versus-host disease after a stem cell transplant

  This will test whether adding the drug belumosudil to standard prevention lowers the risk of graft-versus-host disease in adults with blood cancers after a stem cell transplant.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT07006506

• Adding emapalumab to standard post-transplant medicines to prevent graft‑versus‑host disease after reduced‑intensity donor stem cell transplant

  This trial will test whether adding emapalumab to post‑transplant cyclophosphamide, tacrolimus, and mycophenolate mofetil can prevent graft‑versus‑host disease in adults with AML or MDS receiving a reduced‑intensity donor stem cell transplant.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06996119

• Group telehealth program to help adults with chronic graft-versus-host disease

  This program tests whether the HORIZONS group telehealth sessions help adults with moderate to severe chronic graft-versus-host disease manage symptoms and improve quality of life compared with usual care.

  Recruiting at 2 sites Massachusetts General Hospital · Miami, Florida and 1 other locations · NCT06910969

• Vedolizumab with post-transplant cyclophosphamide and short-course tacrolimus to prevent graft-versus-host disease after reduced-intensity allogeneic stem cell transplant

  This trial tests whether adding vedolizumab to post-transplant cyclophosphamide and a short course of tacrolimus can prevent graft-versus-host disease in adults getting reduced-intensity allogeneic stem cell transplants for leukemias or related blood disorders.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06815003

• Reduced versus standard dose post-transplant cyclophosphamide with tacrolimus and a single low-dose ATG to prevent GVHD after alternative-donor peripheral stem cell transplant

  This trial will see if a lower dose (35 mg/kg) of post-transplant cyclophosphamide plus tacrolimus and one low dose of ATG prevents graft-versus-host disease as well as the standard 50 mg/kg dose in patients receiving an allogeneic peripheral stem cell transplant from an unrelated or haploidentical donor.

  Recruiting Phase 3 Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT06705062

• Comparing Rovadicitinib to Other Treatments for Chronic Graft-versus-host Disease

  This study is testing if Rovadicitinib can help people with moderate to severe chronic graft-versus-host disease who haven't found relief from other treatments.

  Recruiting at 2 sites Phase 3 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Hefei, Anhui and 40 other locations · NCT06682169

• Comparing two types of stem cell transplants for children

  This study is testing whether a new type of stem cell transplant can reduce complications and improve life for children who need this treatment.

  Recruiting Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT06423131

• Injecting bone marrow cells to treat dry mouth

  This study is testing if injecting special cells from bone marrow into the salivary glands can help people with dry mouth caused by conditions like Sjögren's disease feel better.

  Recruiting Phase 1 University of Wisconsin, Madison · Madison, Wisconsin · NCT06392711

• Using Optical Coherence Tomography to Diagnose Oral Cancer

  This study is testing if a special imaging technique called Optical Coherence Tomography can help doctors find oral cancer earlier and more accurately in patients with potentially harmful mouth conditions.

  Recruiting University of Palermo · Palermo · NCT06321003

• Testing a new approach to prevent graft-versus-host disease after stem cell transplantation

  This study is testing a new treatment to see if a combination of two drugs can help prevent graft-versus-host disease in patients receiving stem cell transplants, allowing them to stop taking immunosuppressive drugs sooner.

  Recruiting at 3 sites Phase 2 Nantes University Hospital · Angers and 2 other locations · NCT06252870

• Using Ruxolitinib to prevent complications after haploidentical stem cell transplants

  This study is testing if the drug Ruxolitinib can help prevent complications like graft-versus-host disease in patients receiving stem cell transplants from partially matched donors.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT06008808

• Using Ruxolitinib to prevent complications after haploidentical stem cell transplants

  This study is testing if the drug Ruxolitinib can help prevent complications like graft-versus-host disease in patients receiving stem cell transplants from partially matched donors.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT06008808

• Using parametric response mapping to detect lung injury in transplant patients

  This study is testing if a new imaging method can help predict lung problems in transplant patients who have chronic graft versus host disease or chronic lung disease.

  Recruiting at 3 sites University of Michigan Rogel Cancer Center · Stanford, California and 5 other locations · NCT05866302

• Using light therapy to treat oral Graft-Versus-Host Disease after stem cell transplant

  This study tests if a special light therapy can help people with oral Graft-Versus-Host Disease after a stem cell transplant feel better when other treatments haven't worked.

  Recruiting at 9 sites Phase 2 Memorial Sloan Kettering Cancer Center · Bethesda, Maryland and 8 other locations · NCT05675930

• Post-Transplant GvHD Prophylaxis with PTCy, Bortezomib, and Abatacept

  This study tests whether adding abatacept to a standard post-transplant prophylaxis (PTCy and bortezomib) can reduce graft-versus-host disease in adults after allogeneic HSCT from matched related or matched/unrelated donors.

  Recruiting Phase 1/2 Northwell Health · New Hyde Park, New York · NCT05289167

• Combining post-transplant cyclophosphamide with uhCG/EGF for preventing Graft Versus Host Disease

  This study is testing if a new combination of medications can help prevent Graft Versus Host Disease in patients with blood cancers who are getting stem cell transplants from unrelated donors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT04886726

• Exploring the link between FODMAPs and Graft Versus Host Disease

  This study is trying to see if certain foods called FODMAPs affect the severity of Graft Versus Host Disease in patients who have had a bone marrow transplant.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT04660487

• Using CliniMACS for T-Cell Depletion in Stem Cell Transplant

  This study is testing if a special device can safely remove certain T-cells from donor blood to help patients getting a stem cell transplant avoid complications like graft-versus-host disease.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04337515

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Improved methods for selecting cells in bone marrow transplants

  This study is testing new ways to select cells from healthy donors for bone marrow transplants to see if it can make the procedure safer and more effective for patients with blood disorders.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001529

NIH-funded research (35)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting early oral GVHD to improve mouth health after stem cell transplant

  A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11616478

• Microbiome-based therapy for treatment-refractory GVHD after stem cell transplant

  A microbiome-based therapy is being developed to help people who have graft-versus-host disease that doesn’t respond to standard treatments after a stem cell transplant.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11425530

• Role of altered mitochondria in preventing GVHD after stem cell transplant

  This NIH grant explores how damaged mitochondria released during pre-transplant conditioning may trigger graft-versus-host disease and tests ways to fix mitochondrial dynamics to prevent GVHD.

  NIH research Stanford University · Stanford, United States · NIH-11378688

• Fecal transplant plus fiber to treat graft-versus-host disease after blood stem cell transplant

  A study to see if giving fecal transplant along with dietary fiber helps gut health and reduces complications in patients who have received a stem cell transplant and developed graft-versus-host disease.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11377663

• Using medium-chain fatty acids and a fat-sensing receptor to treat chronic graft-versus-host disease

  This project looks at whether changing medium‑chain fatty acids or blocking a fat sensor called GPR84 can help people with chronic graft‑versus‑host disease after a bone marrow/stem cell transplant.

  NIH research University of Central Florida · Orlando, United States · NIH-11325709

• Microbiome-based oral therapy for gut GVHD after stem cell transplant

  Researchers are testing an oral live Biotherapeutic Product to help the gut microbiome improve graft-versus-host disease after stem cell transplant patients.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11320120

• How the protein ID3 controls donor T cells that cause GVHD and fight leukemia

  Researchers are looking at whether changing the activity of a protein called ID3 in donor T cells can lower graft-versus-host disease while keeping those cells able to attack leukemia after a stem cell transplant.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11317224

• Bile acids and gut graft‑versus‑host disease

  Researchers will measure bile acids and related metabolites to find how they affect gut graft‑versus‑host disease in people who’ve had allogeneic stem cell transplants.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11310114

• Blood and immune cell markers to predict chronic graft‑versus‑host disease

  Using machine learning on blood and immune cell tests, this project looks for early signs that children and adults who had bone marrow (allogeneic) transplants may develop chronic graft‑versus‑host disease.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11304070

• Mechanical cues to boost stem cell therapy for graft-versus-host disease

  Researchers are testing a way to make stem cells more powerful at calming immune reactions in people with graft-versus-host disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11298671

• Role of autoreactivity in chronic graft-versus-host disease

  This grant explores how the body’s immune cells contribute to chronic GVHD after donor stem cell transplant, with the goal of preventing or treating this serious complication.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11293459

• Understanding how a specific type of T helper cell drives gut GVHD and how to target it safely

  A Purdue-led study will look at a special group of CD4 T helper cells that fuel gut GVHD after cancer treatment, with the goal of blocking them without hurting anti-cancer effects.

  NIH research Purdue University · West Lafayette, United States · NIH-11275854

• Stopping graft-versus-host disease by targeting tissue-resident T cells

  This research tests whether long-lived T cells that live inside organs keep causing graft-versus-host disease in people who received donor stem cell transplants.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11261635

• Immune signals that drive gut graft-versus-host disease

  This project looks at specific immune signaling proteins and the T cells that make them in people who develop gut inflammation after a donor stem-cell transplant.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11229598

• Investigating the role of IL-39 in graft-versus-host disease

  This study is looking at how a substance called IL-39 affects the immune response in people who have had a bone marrow transplant and are at risk for graft-versus-host disease (GVHD), with the goal of finding new ways to help manage this condition.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11140887

• Using Fecal Microbiota Transplantation and Fiber to Treat Graft-versus-host Disease After Stem Cell Transplants

  This work explores how giving patients healthy gut bacteria and fiber might help manage graft-versus-host disease, a common issue after stem cell transplants.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11137074

• Investigating how medium chain fatty acids affect chronic graft-versus-host disease

  This study is looking at how certain fatty acids might affect T cells and contribute to chronic graft-versus-host disease (cGVHD) after stem cell transplants, with the hope of finding new ways to help patients feel better.

  NIH research University of Central Florida · Orlando, United States · NIH-11092858

• Investigating bile acids in graft-versus-host disease

  This study is looking at how bile acids and gut bacteria might affect graft-versus-host disease (GVHD) in patients who have had a stem cell transplant, with the goal of finding new ways to improve treatment and outcomes for those facing this condition.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11085255

• Understanding how T cells affect graft-versus-host disease and leukemia treatment

  This study is looking at how certain immune cells called T cells affect the success of stem cell transplants for blood cancers like leukemia, with the goal of finding better ways to reduce complications like graft-versus-host disease while still helping to fight the cancer.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11081734

• Better Understanding Chronic Graft-Versus-Host Conditions

  This project aims to better understand chronic graft-versus-host disease (cGVHD) in people who have received a stem cell transplant, hoping to find ways to personalize their care.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11066490

• Understanding how immune cells contribute to chronic graft versus host disease

  This study is looking at how certain immune cells contribute to chronic graft versus host disease (cGVHD) after a stem cell transplant, with the goal of finding new ways to prevent or treat this condition, so patients can potentially benefit from better treatments in the future.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11061894

• Understanding how graft-versus-host disease is maintained in patients after stem cell transplants

  This study is looking into how graft-versus-host disease (GVHD) happens after stem cell transplants, to find out if it’s caused by T cells in the lymph nodes or in the tissues themselves, with the goal of creating better treatments that reduce GVHD while still helping patients benefit from their transplants.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11049577

• Understanding how gut bacteria affect the risk of graft-versus-host disease after stem cell transplants

  This study is looking at how the bacteria in your gut might affect the risk of developing graft-versus-host disease (GVHD) after a stem cell transplant, and it aims to create easy-to-use tools that help doctors understand this connection better to improve patient care.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11023128

• Using machine learning to find early signs of chronic graft-versus-host disease after blood stem cell transplants

  This study is looking for clues in blood samples from patients who have had a stem cell transplant to help predict if they might develop chronic graft-versus-host disease (cGVHD), so that doctors can catch it early and provide better treatment.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11001469

• Identifying biomarkers to predict treatment resistance in chronic graft-versus-host disease

  This study is looking at ways to better understand chronic graft-versus-host disease (cGVHD) after a bone marrow transplant by checking blood samples to find markers that can help predict how well different treatments will work for patients, with the goal of improving their care.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10912787

• Using fecal microbiota transplantation and fiber to treat graft-versus-host disease after blood cell transplants

  This study is looking at how using a special treatment called fecal microbiota transplantation, along with dietary fiber, can help improve gut health and recovery for patients dealing with graft-versus-host disease after a stem cell transplant.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10908690

• Improving the immune response of stem cells to treat graft-versus-host disease.

  This study is looking at ways to make special stem cells better at helping people with graft-versus-host disease (GvHD) by creating a more natural environment for them to grow, which could lead to improved treatments for patients who have had stem cell transplants.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10905160

• Ustekinumab to prevent graft-versus-host disease after donor stem cell transplant

  This trial gives the drug ustekinumab alongside usual immune-suppressing medicines to people receiving unrelated donor stem cell transplants to try to prevent graft-versus-host disease.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10891411

• Understanding and Treating Eye Problems After Stem Cell Transplants

  This research aims to understand why the eyes are affected by Graft versus Host Disease after stem cell transplants and to find new ways to help patients.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10823360

• Blocking IL-23 to prevent complications after bone marrow transplants

  This study is looking at whether blocking a substance called IL-23 can help prevent a serious condition called graft versus host disease (GVHD) that can happen after bone marrow transplants, and it's aimed at helping people who are getting these transplants.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10818392

• Investigating genetic markers and antibody responses to predict chronic graft-versus-host disease

  This study is looking for clues in your genes and immune responses that might help doctors predict if you'll develop chronic graft-versus-host disease after a stem cell transplant, so if you join, you may have some tests done to help us learn more about this condition.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10809751

• Tracking immune responses after blood stem cell transplants using blood tests

  This study is working on a simple blood test that can help people who have had blood stem cell transplants by spotting early signs of graft-versus-host disease (GVHD) without needing painful biopsies, making it easier for patients to keep track of their health.

  NIH research Cornell University · Ithaca, United States · NIH-10754512

• Understanding how T cells contribute to complications after stem cell transplants

  This study is looking at how certain immune cells called T cells behave after a stem cell transplant and how they might contribute to a condition called Graft Versus Host Disease (GVHD), with the goal of finding better ways to prevent or treat this serious complication for patients.

  NIH research Loyola University Chicago · Maywood, United States · NIH-10684330

• Using ustekinumab to prevent graft versus host disease after stem cell transplants

  This study is looking at whether a medication called ustekinumab can help prevent graft versus host disease (GVHD) in people getting stem cell transplants, especially from unrelated donors, to improve their chances of recovery and overall well-being.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10681200

• Understanding how inflammation affects patients after bone marrow transplants

  This study is looking at how inflammation from graft versus host disease (GVHD) after a bone marrow transplant can affect thinking and behavior, and it's trying to find new ways to help manage these symptoms.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10627875

Related topics

Quick answers

How many Graft Versus Host Disease clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (16 trials), China (7 trials), France (2 trials), Italy (2 trials), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1: 5, Phase 3: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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