Using fecal microbiota transplantation and fiber to treat graft-versus-host disease after blood cell transplants

Who could benefit from this research

What this research studies

This research investigates the use of fecal microbiota transplantation (FMT) combined with dietary fiber to treat graft-versus-host disease (GvHD) in patients who have undergone allogeneic hematopoietic cell transplantation. GvHD is a serious complication that affects many transplant recipients, leading to significant health issues. The study aims to explore how different methods of delivering FMT can help restore gut bacteria and improve patient outcomes. By understanding the role of gut microbiota in GvHD, the research seeks to identify effective treatment strategies that could enhance recovery and quality of life for patients.

Why it matters

Where this research is happening

• Fred Hutchinson Cancer Center
  Seattle, United States Active

Researchers

• Principal investigator: Fredricks, David Neal — Fred Hutchinson Cancer Center
• Study coordinator: Fredricks, David Neal

Related research

Other NIH-funded projects on the same topics.

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• Using Fecal Microbiota Transplantation and Fiber to Treat Graft-versus-host Disease After Stem Cell Transplants

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  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11137074

• Proteolytic Activity-Guided Fecal Microbiota Transplant for PI-IBS

  A pilot study will test a targeted fecal microbiota transplant to help adults with post-infection irritable bowel syndrome feel better and have fewer GI symptoms.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11377587

• Fecal microbiota transplantation plus immune checkpoint blockers for solid tumors

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  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11364138

• Fecal transplant treatment for auto-brewery (gut fermentation) syndrome

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  NIH research University of California, San Diego · La Jolla, United States · NIH-11197592

• A new way to use gut bacteria transplants for Irritable Bowel Syndrome

  This research explores if a special type of fecal microbiota transplant, guided by specific gut enzyme activity, can safely and effectively improve symptoms for adults with Irritable Bowel Syndrome that developed after an infection.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11176806

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.