Identifying biomarkers to predict treatment resistance in chronic graft-versus-host disease
Chronic Graft-Versus-Host Disease Biomarkers: Prediction of Resistance to Therapy
This study is looking at ways to better understand chronic graft-versus-host disease (cGVHD) after a bone marrow transplant by checking blood samples to find markers that can help predict how well different treatments will work for patients, with the goal of improving their care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10912787 on NIH RePORTER |
What this research studies
This research focuses on chronic graft-versus-host disease (cGVHD), a condition that can occur after a bone marrow transplant. It aims to identify biomarkers that can predict how well patients will respond to specific therapies for cGVHD. By analyzing blood samples from patients undergoing treatment, the researchers will explore whether certain biological markers can indicate resistance to therapy and help improve patient outcomes. The study utilizes advanced proteomic techniques to uncover these potential biomarkers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with steroid-refractory or steroid-dependent chronic graft-versus-host disease.
Not a fit: Patients who do not have chronic graft-versus-host disease or those who are not undergoing treatment for this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for patients with cGVHD, improving their chances of recovery.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for treatment response in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Paczesny, Sophie — Medical University of South Carolina
- Study coordinator: Paczesny, Sophie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.