Identifying biomarkers to predict treatment resistance in chronic graft-versus-host disease
Official title: Chronic Graft-Versus-Host Disease Biomarkers: Prediction of Resistance to Therapy
Funded at Medical University of South Carolina · NIH-10912787 · Data updated 2026-11-12
This study is looking at ways to better understand chronic graft-versus-host disease (cGVHD) after a bone marrow transplant by checking blood samples to find markers that can help predict how well different treatments will work for patients, with the goal of improving their care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 23, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $188,750 |
| NIH project number | 5R21AI178981-02 |
| Project ID | NIH-10912787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with steroid-refractory or steroid-dependent chronic graft-versus-host disease.
✕Less likely to help
Patients who do not have chronic graft-versus-host disease or those who are not undergoing treatment for this condition may not benefit from this research.
What this research studies
This research focuses on chronic graft-versus-host disease (cGVHD), a condition that can occur after a bone marrow transplant. It aims to identify biomarkers that can predict how well patients will respond to specific therapies for cGVHD. By analyzing blood samples from patients undergoing treatment, the researchers will explore whether certain biological markers can indicate resistance to therapy and help improve patient outcomes. The study utilizes advanced proteomic techniques to uncover these potential biomarkers.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for patients with cGVHD, improving their chances of recovery.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for treatment response in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Paczesny, Sophie — Medical University of South Carolina
- Study coordinator: Paczesny, Sophie
Related research
Other NIH-funded projects on the same topics.
-
Targeting early oral GVHD to improve mouth health after stem cell transplant
A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.
-
Microbiome-based therapy for treatment-refractory GVHD after stem cell transplant
A microbiome-based therapy is being developed to help people who have graft-versus-host disease that doesn’t respond to standard treatments after a stem cell transplant.
-
Role of altered mitochondria in preventing GVHD after stem cell transplant
This NIH grant explores how damaged mitochondria released during pre-transplant conditioning may trigger graft-versus-host disease and tests ways to fix mitochondrial dynamics to prevent GVHD.
-
Fecal transplant plus fiber to treat graft-versus-host disease after blood stem cell transplant
A study to see if giving fecal transplant along with dietary fiber helps gut health and reduces complications in patients who have received a stem cell transplant and developed graft-versus-host disease.
-
Using medium-chain fatty acids and a fat-sensing receptor to treat chronic graft-versus-host disease
This project looks at whether changing medium‑chain fatty acids or blocking a fat sensor called GPR84 can help people with chronic graft‑versus‑host disease after a bone marrow/stem cell transplant.
-
Microbiome-based oral therapy for gut GVHD after stem cell transplant
Researchers are testing an oral live Biotherapeutic Product to help the gut microbiome improve graft-versus-host disease after stem cell transplant patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.