Investigating genetic markers and antibody responses to predict chronic graft-versus-host disease
IGHG Genes (GM Allotypes) and Anti-CMV (UL70) Antibody Responses as Prognostic Markers for Chronic Graft-Versus-Host-Disease
This study is looking for clues in your genes and immune responses that might help doctors predict if you'll develop chronic graft-versus-host disease after a stem cell transplant, so if you join, you may have some tests done to help us learn more about this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10809751 on NIH RePORTER |
What this research studies
This research focuses on identifying genetic markers and antibody responses that could help predict the onset of chronic graft-versus-host disease (cGVHD) in patients who have undergone hematopoietic cell transplantation (HCT). By examining immunoglobulin GM genes and their relationship with cytomegalovirus (CMV) infections, the study aims to uncover biomarkers that can indicate which patients are at higher risk for developing cGVHD. The approach involves analyzing the interaction between GM alleles and antibody responses to CMV, which may influence the immune response and disease progression. Patients participating in this research may undergo genetic testing and antibody assessments to contribute to the understanding of cGVHD risk factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have undergone hematopoietic cell transplantation.
Not a fit: Patients who have not received a hematopoietic cell transplant or those without a history of chronic graft-versus-host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early identification of patients at risk for chronic graft-versus-host disease, allowing for timely interventions.
How similar studies have performed: Other research has shown promise in identifying genetic markers for various autoimmune conditions, suggesting that this approach may yield valuable insights for cGVHD as well.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Pandey, Janardan P — Medical University of South Carolina
- Study coordinator: Pandey, Janardan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.