Condition

Graft Vs Host Disease clinical trials and research

• 18Clinical trials
• 8NIH research projects
• 6Countries

Newest Graft Vs Host Disease clinical trials

All recruiting trials (18)

• Low-dose liposomal amphotericin B to prevent invasive fungal infections in neutropenic children

  This study tests whether giving a fixed low dose of liposomal amphotericin B can prevent invasive fungal infections in children aged 3–17 who are severely neutropenic after hematopoietic stem cell transplantation or similar high-risk conditions.

  Recruiting Haikou Affiliated Hospital of Central South University Xiangya School of Medicine · Haikou, Hainan · NCT07725263

• Madecassoside tablets plus standard therapy for sclered scl-cGVHD after allo-HSCT

  This study tests whether adding madecassoside tablets to standard therapy can help people with scleral chronic graft-versus-host disease after stem cell transplant.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07606703

• T-cell–guided letermovir stopping after allogeneic stem cell transplant

  This tests whether using a CMV-specific T-cell blood test to decide when adult CMV-positive patients can stop letermovir after allogeneic stem cell transplant keeps them protected while avoiding unnecessary drug exposure.

  Recruiting Phase 4 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Beijing, Beijing Municipality and 11 other locations · NCT07569653

• Fatigue and thinking problems after allogeneic stem cell transplant (synapse damage or brain GVHD)

  This project uses PET scans and spinal fluid samples to try to find why people who had an allogeneic stem cell transplant have persistent fatigue and thinking problems.

  Recruiting Karolinska University Hospital · Stockholm · NCT07365696

• Fecal microbiota transplantation for steroid-refractory acute GI-GvHD

  This trial tests whether fecal microbiota transplantation can help adults with steroid-refractory acute gastrointestinal graft-versus-host disease after stem cell transplant.

  Recruiting Phase 2 Chang Gung Memorial Hospital · Taoyuan · NCT07364617

• Adding etanercept to ruxolitinib for severe steroid-refractory acute GVHD

  This trial will test whether adding the TNF blocker etanercept to ruxolitinib helps people with severe acute GVHD that did not respond to steroids.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT07184853

• Belumosudil to prevent graft-versus-host disease after a stem cell transplant

  This will test whether adding the drug belumosudil to standard prevention lowers the risk of graft-versus-host disease in adults with blood cancers after a stem cell transplant.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT07006506

• Ruxolitinib for corticosteroid-refractory chronic graft-versus-host disease in Chinese patients

  This trial will try ruxolitinib in Chinese adolescents (12+) and adults whose chronic graft-versus-host disease has not improved with corticosteroids.

  Recruiting at 22 sites Phase 4 Novartis · Hefei, Anhui and 21 other locations · NCT06824103

• Evaluating vulvovaginal graft-versus-host disease and the vaginal microbiome

  This study is trying to see how changes in the vaginal bacteria of women who have a stem cell transplant might relate to the development of vulvovaginal graft-versus-host disease.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06649201

• Single high-dose vitamin A given with allogeneic stem cell transplant

  This study tests whether giving one large oral dose of vitamin A to adults having an allogeneic stem cell transplant can lower the chance of moderate-to-severe chronic graft-versus-host disease.

  Recruiting at 3 sites Phase 2 Children's Hospital Medical Center, Cincinnati · Tampa, Florida and 2 other locations · NCT06450925

• Using Ruxolitinib to prevent complications after haploidentical stem cell transplants

  This study is testing if the drug Ruxolitinib can help prevent complications like graft-versus-host disease in patients receiving stem cell transplants from partially matched donors.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT06008808

• Testing pacritinib for treating severe chronic graft-versus-host disease after stem cell transplant

  This study is testing if a new oral medication called pacritinib can help adults with severe chronic graft-versus-host disease who haven't found relief from other treatments.

  Recruiting at 2 sites Phase 1/2 National Institutes of Health Clinical Center (CC) · Miami, Florida and 1 other locations · NCT05531786

• Understanding how extracorporeal photochemotherapy causes cell death

  This study is trying to understand how a treatment called extracorporeal photochemotherapy helps patients with skin lymphomas and graft-versus-host disease by looking at how it causes certain cells to die.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT05333367

• Understanding Ocular Graft-Versus-Host Disease After Bone Marrow Transplant

  This study is trying to understand how common eye problems are in people who have had a bone marrow transplant and see if certain factors can help improve their care.

  Recruiting The University of Hong Kong · Hong Kong · NCT05170347

• New approach to stem cell transplant for high-risk leukemia patients

  This study is testing a new type of stem cell transplant for high-risk leukemia patients to see if it can help them recover better and avoid complications.

  Recruiting Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT04678401

• Extended versus short abatacept dosing to prevent graft-versus-host disease after mismatched unrelated donor transplant

  This trial tests whether giving extra abatacept doses after a 7/8 matched unrelated donor stem cell transplant helps prevent severe acute and chronic graft-versus-host disease in patients already receiving standard calcineurin inhibitor plus methotrexate prophylaxis.

  Recruiting at 4 sites Phase 2 Boston Children's Hospital · Duarte, California and 14 other locations · NCT04380740

• Using CliniMACS for T-Cell Depletion in Stem Cell Transplant

  This study is testing if a special device can safely remove certain T-cells from donor blood to help patients getting a stem cell transplant avoid complications like graft-versus-host disease.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04337515

• Long-term follow-up care for patients who received stem cell transplants

  This study looks at how people aged 10 to 80 who received stem cell transplants are doing over time to see how well they respond to treatment and if they have any long-term issues.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00106925

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ChronicGVHD: How it happens and new ways to treat it

  A large NIH grant is funding research on chronic graft-versus-host disease after stem cell transplant, with a focus on the lungs and other organs, to improve outcomes for patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11411246

• Propagation of GVHD through CD4+ T-cell recognition of gut bacteria

  Researchers are studying how a patient’s immune cells recognize gut bacteria after stem cell transplant to better understand and manage graft-versus-host disease.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11377412

• How donor DNA affects immune responses in blood stem cell transplants

  This study is looking at how changes in donor DNA can help improve the success of stem cell transplants by boosting the body's ability to fight cancer while lowering the chances of complications, and it's aimed at helping patients who are getting these transplants.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11263108

• Understanding and treating chronic graft-versus-host disease and its lung form, bronchiolitis obliterans

  This project works to find new treatments that block immune and metabolic drivers of chronic GVHD and bronchiolitis obliterans in people after allogeneic stem cell transplant.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11174465

• How donor DNA affects immune responses in blood stem cell transplants

  This study is looking at how changes in DNA from donor cells can affect the immune system during stem cell transplants, with the goal of finding better ways to help patients with serious cancers avoid complications while still fighting the disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11073092

• Understanding and treating chronic graft-versus-host disease

  This study is looking at how chronic graft-versus-host disease (cGVHD) affects the lungs after a stem cell transplant, and it aims to find new ways to help patients by understanding the immune cells involved in this condition.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10914131

• Understanding how Galectin-3 affects Graft vs. Host Disease and Graft vs. Tumor responses

  This study is looking at how a protein called Galectin-3 affects the immune responses in patients who have received a stem cell transplant, with the hope of finding ways to reduce complications like Graft vs. Host Disease and improve recovery.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-10857141

• How gut bacteria influence graft vs. host disease after stem cell transplants

  This study is looking at how certain immune cells called T-cells interact with the bacteria in the gut after a stem cell transplant, to better understand how these interactions might affect the development and severity of graft vs. host disease (GVHD), which can make recovery harder for patients.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10834980

Related topics

Quick answers

How many Graft Vs Host Disease clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), China (5 trials), France (1 trial), Hong Kong (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 2, Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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