Better Understanding Chronic Graft-Versus-Host Conditions
Improving Outcomes Assessment in Chronic Graft versus Host Disease
This project aims to better understand chronic graft-versus-host disease (cGVHD) in people who have received a stem cell transplant, hoping to find ways to personalize their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11066490 on NIH RePORTER |
What this research studies
After a stem cell transplant, many survivors develop chronic graft-versus-host disease (cGVHD), a serious complication that can affect many parts of the body and significantly impact quality of life. This condition often requires long-term treatment with strong medications. We are working to fill important gaps in our knowledge about cGVHD by studying a large number of patient samples from our extensive collection. Our goal is to identify different groups of patients with cGVHD based on their unique biological markers, such as proteins in their blood and specific cell types. This could help us understand why cGVHD affects people differently and lead to more personalized treatment approaches.
Who could benefit from this research
Good fit: Patients who have undergone allogeneic hematopoietic cell transplantation and developed chronic graft-versus-host disease are the focus of this research.
Not a fit: Patients who have not received an allogeneic hematopoietic cell transplant or do not have chronic graft-versus-host disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more tailored and effective treatments for chronic graft-versus-host disease, improving the lives of transplant survivors.
How similar studies have performed: While previous studies have provided some insights, this project aims to address key gaps by studying larger patient numbers and using advanced techniques to identify distinct patient subgroups, representing a novel approach to understanding cGVHD.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Lee, Stephanie J — Fred Hutchinson Cancer Center
- Study coordinator: Lee, Stephanie J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.