Investigating bile acids in graft-versus-host disease
Official title: The role of bile acid metabolomics in graft-versus-host disease
Funded at Beckman Research Institute/city of Hope · NIH-11085255 · Data updated 2026-11-12
This study is looking at how bile acids and gut bacteria might affect graft-versus-host disease (GVHD) in patients who have had a stem cell transplant, with the goal of finding new ways to improve treatment and outcomes for those facing this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | March 15, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $585,843 |
| NIH project number | 5R01CA228308-08 |
| Project ID | NIH-11085255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing allogeneic hematopoietic cell transplantation who are at risk for developing graft-versus-host disease.
✕Less likely to help
Patients who have not undergone allogeneic hematopoietic cell transplantation or those with pre-existing gastrointestinal conditions unrelated to GVHD may not benefit from this research.
What this research studies
This research focuses on understanding how bile acids and their metabolites influence graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (allo-HCT). By analyzing the intestinal microbiome and bile acid profiles in patients, the study aims to uncover relationships between these factors and the development of GVHD. The approach combines advanced sequencing techniques with immunological and metabolomic analyses to identify potential biomarkers and therapeutic targets. Patients may be monitored for changes in their microbiome and bile acid levels to better understand their impact on GVHD outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment strategies for patients suffering from graft-versus-host disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of the intestinal microbiome in GVHD, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Van Den Brink, Marcel R M — Beckman Research Institute/city of Hope
- Study coordinator: Van Den Brink, Marcel R M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.