Understanding how T cells affect graft-versus-host disease and leukemia treatment
Official title: ID3 regulation of tissue-infiltrating T cells mediating graft-versus-host disease and leukemia rejection
Funded at Hackensack University Medical Center · NIH-11081734 · Data updated 2026-11-12
This study is looking at how certain immune cells called T cells affect the success of stem cell transplants for blood cancers like leukemia, with the goal of finding better ways to reduce complications like graft-versus-host disease while still helping to fight the cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $733,555 |
| NIH project number | 5R01CA290808-02 |
| Project ID | NIH-11081734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing allogeneic hematopoietic stem cell transplantation for hematological cancers such as leukemia, lymphoma, or myeloma.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those with solid tumors may not benefit from this research.
What this research studies
This research investigates the role of specific T cells in graft-versus-host disease (GVHD) and their impact on the success of stem cell transplants for treating blood cancers like leukemia. The study focuses on how these T cells persist in the body and how they can be better managed to reduce GVHD while still effectively fighting cancer. By exploring the mechanisms that allow these T cells to survive and function, the research aims to develop improved strategies for managing GVHD and preventing cancer relapse after transplantation.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients undergoing stem cell transplants, reducing the risk of GVHD and improving cancer outcomes.
How similar studies have gone: Previous research has shown promise in managing GVHD through various immunosuppressive strategies, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Hackensack University Medical Center
Hackensack, United States Active
Researchers
- Principal investigator: Zhang, Yi — Hackensack University Medical Center
- Study coordinator: Zhang, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.