Understanding how graft-versus-host disease is maintained in patients after stem cell transplants
Graft-versus-Host Disease: Local Maintenance by Tissue Resident Progenitor T cells
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11049577
This study is looking into how graft-versus-host disease (GVHD) happens after stem cell transplants, to find out if it’s caused by T cells in the lymph nodes or in the tissues themselves, with the goal of creating better treatments that reduce GVHD while still helping patients benefit from their transplants.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11049577 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind graft-versus-host disease (GVHD), a condition that can occur after allogeneic stem cell transplants. The study aims to determine whether GVHD is sustained by T cells generated in the lymph nodes or if it is maintained locally in the tissues where it occurs. By analyzing specific T cell behaviors in a controlled model, the researchers hope to develop targeted therapies that minimize GVHD while preserving the beneficial effects of the transplant. This could lead to improved treatment strategies for patients undergoing stem cell transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have received allogeneic stem cell transplants and are experiencing or at risk of developing graft-versus-host disease.
Not a fit: Patients who have not undergone stem cell transplantation or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for graft-versus-host disease, improving outcomes for patients who have undergone stem cell transplants.
How similar studies have performed: Previous research has shown promise in understanding T cell behavior in GVHD, suggesting that targeted approaches could be effective, although this specific focus on local maintenance is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHLOMCHIK, WARREN D — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: SHLOMCHIK, WARREN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.