Blocking IL-23 to prevent complications after bone marrow transplants
Blockade of IL-23 for the Prevention of Graft Versus Host Disease
This study is looking at whether blocking a substance called IL-23 can help prevent a serious condition called graft versus host disease (GVHD) that can happen after bone marrow transplants, and it's aimed at helping people who are getting these transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10818392 on NIH RePORTER |
What this research studies
This research investigates how blocking a specific inflammatory cytokine, IL-23, can help prevent graft versus host disease (GVHD), a serious complication that can occur after bone marrow transplants. The study aims to understand the mechanisms by which IL-23 contributes to inflammation in the gastrointestinal tract during GVHD. By conducting experiments in mice and translating these findings to human patients, the researchers hope to determine if targeting IL-23 can reduce the severity of GVHD in individuals receiving allogeneic hematopoietic stem cell transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are scheduled to receive allogeneic hematopoietic stem cell transplants.
Not a fit: Patients who are not undergoing bone marrow transplants or those with pre-existing severe gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk and severity of GVHD in patients undergoing bone marrow transplants.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory cytokines for similar conditions, suggesting that this approach may be effective.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Drobyski, William R. — Medical College of Wisconsin
- Study coordinator: Drobyski, William R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.