Understanding how immune cells contribute to chronic graft versus host disease
Role of autoreactivity in pathogenesis of chronic graft versus host disease
This study is looking at how certain immune cells contribute to chronic graft versus host disease (cGVHD) after a stem cell transplant, with the goal of finding new ways to prevent or treat this condition, so patients can potentially benefit from better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11061894 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells in the development of chronic graft versus host disease (cGVHD) following allogeneic hematopoietic cell transplantation. By studying interactions between tissue-resident T and B cells in affected organs, the research aims to uncover new therapeutic targets that could help prevent or treat cGVHD. The approach includes using advanced models and biospecimens from patients to gain insights into the disease mechanisms. Patients may benefit from potential new treatments that arise from this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone allogeneic hematopoietic cell transplantation and are experiencing symptoms of chronic graft versus host disease.
Not a fit: Patients who have not undergone allogeneic hematopoietic cell transplantation or do not have chronic graft versus host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the incidence and severity of chronic graft versus host disease.
How similar studies have performed: Previous research has shown promising results in understanding immune mechanisms in graft versus host disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Zeng, Defu — Beckman Research Institute/city of Hope
- Study coordinator: Zeng, Defu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.