Condition

Fertility clinical trials and research

• 13Clinical trials
• 90NIH research projects
• 11Countries

Newest Fertility clinical trials

All recruiting trials (13)

• Reproductive outlook for women trying to conceive after medical or surgical treatment for endometriosis

  This study will try to see whether women treated medically or surgically for endometriosis are more likely to need medically assisted reproduction (PMA) and how their conception and pregnancy outcomes compare.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, MI, Italia · NCT07437742

• Plan A male contraceptive system to block and restore sperm flow

  This test checks whether the Plan A male contraceptive system can block sperm by occluding the vas deferens and later be reversed in men seeking vasectomy-like contraception.

  Recruiting at 2 sites Phase 2 Next Life Sciences · Maribyrnong, Victoria and 2 other locations · NCT07361120

• Fertility-preserving care for endometrial cancer guided by tumor molecular type

  This trial tests whether choosing fertility-preserving medicines based on a tumor's molecular subtype helps women with early endometrial cancer keep their fertility.

  Recruiting Phase 2/3 Fudan University · Shanghai, Shanghai Municipality and 1 other locations · NCT07319429

• Surgical options to preserve ovaries when treating endometriomas

  This trial will see if different surgical methods for treating endometriomas help women who want to get pregnant have higher pregnancy and birth rates and fewer complications.

  Recruiting Clinique Tivoli Ducos · Bordeaux · NCT07119060

• Adjuvant melanoma treatments and fertility after surgery

  This project will test whether adjuvant immunotherapy or targeted MAPK inhibitor drugs affect fertility in women under 40 after melanoma surgery.

  Recruiting Intergruppo Melanoma Italiano · Bari and 9 other locations · NCT07092670

• Impact of physical activity on fertility and pregnancy outcomes in Danish couples

  This study is testing if getting more physical activity and support can help women trying to conceive have healthier pregnancies and better outcomes.

  Recruiting University of Aarhus · Aarhus · NCT06705712

• Protecting fertility in young cancer patients

  This study is trying to find ways to help young cancer patients keep their ability to have children after treatment by looking at what might affect their fertility.

  Recruiting University of Ulm · Ulm, Baden-Wurttemberg · NCT06692868

• Evaluating fertility and ovarian function in female childhood cancer survivors

  This study is testing how certain cancer treatments affect the fertility and ovarian health of women who survived childhood cancer to see if they can find new ways to predict ovarian problems later on.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège, Wallonia and 2 other locations · NCT06626282

• Improving egg freezing techniques for fertility treatments

  This study is testing a new way to freeze donor eggs to see if it helps them survive better and leads to more successful pregnancies when used in fertility treatments.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06238570

• Evaluating ovarian stimulation intensity and its effect on embryo quality in older women

  This study tests if using a milder or stronger ovarian stimulation helps older women produce healthy embryos during fertility treatment.

  Recruiting Phase 4 Fundacion Dexeus · Barcelona · NCT06154083

• Investigating the microbiome's effect on pregnancy outcomes in women planning to conceive

  This study is trying to see how the bacteria in the body affect pregnancy outcomes for women who have given birth before and are planning to get pregnant again.

  Recruiting Karolinska Institutet · Stockholm, Huddinge and 1 other locations · NCT05127252

• Impact of Bariatric Surgery on Ovarian Reserve in Obese Women

  This study is testing how bariatric surgery affects the fertility potential of obese women aged 18 to 37 by looking at changes in their hormone levels over a few years.

  Recruiting at 6 sites Assistance Publique - Hôpitaux de Paris · Angers and 13 other locations · NCT04583150

• Fertility preservation for young women with cancer

  This study looks at how well fertility-preserving treatments work for young women with cancer compared to standard cancer treatments to help them understand their options for having children later on.

  Recruiting at 2 sites University Hospital, Gasthuisberg · Leuven and 1 other locations · NCT02878434

NIH-funded research (newest 40 of 90)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how some Amish communities maintain high birth rates in modern times

  A project will build a large, time-sensitive dataset to understand why Amish families keep having many children, even as broader society has much lower birth rates.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11616946

• Fighting fibroids with single-cell data to find new drugs

  A study uses patient fibroid and normal tissue cells to find existing drugs that could be repurposed to treat fibroids, with tests in human cells and a mouse model.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11607753

• Pesticide exposure and fertility health as people move from adolescence to adulthood

  This long-term study follows people in Ecuador to see how pesticide exposure over the years relates to fertility and hormones as they become young adults.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11555862

• CatSper and calcium signaling in sperm fertility

  A study at Yale investigates how a sperm channel called CatSper helps calcium signaling to drive sperm movement and fertility in mammals.

  NIH research Yale University · New Haven, United States · NIH-11537879

• How everyday cosmetic chemicals may affect women's fertility

  This project looks at whether chemicals from cosmetics appear in blood and ovarian fluid and link to fertility in women trying to have children.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11473950

• Chibby proteins' role in sperm development and male fertility

  This project looks at how Chibby family proteins help sperm form and whether problems with these proteins contribute to male infertility.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11472361

• Non-Invasive Test to Predict Recoverable Sperm for Fertility Treatment

  A new non-invasive semen test aims to tell men with infertility whether testicular sperm can be retrieved to support IVF.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11463096

• Ultrasound-guided ovarian tissue grafting platform to help cancer survivors have longer-lasting fertility

  A new ultrasound-guided method aims to improve how ovarian tissue is prepared and transplanted so cancer survivors have a better chance of longer-lasting fertility.

  NIH research Atera Medical · Mountain View, United States · NIH-11456762

• AI-powered microfluidic system to restore fertility in men with azoospermia

  A new AI-guided device helps doctors find and recover extremely rare sperm from men with azoospermia to enable potential fertility treatments.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11456661

• Repurposing approved drugs to protect girls’ fertility during cancer treatment

  This project aims to test existing drugs that can protect the ovaries of young female cancer patients from chemotherapy damage.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11454759

• Maintaining male fertility through RNA binding proteins

  This grant aims to understand how RNA binding proteins help sperm stem cells in males stay healthy and continue producing sperm, using zebrafish as a model to inform potential fertility improvements.

  NIH research University of Massachusetts Boston · Boston, United States · NIH-11444913

• Molecular clues in sperm aggresomes and their impact on fertility

  Sperm carry proteins that can form clumps called aggresomes, and this project looks at how these clumps affect early embryo development in humans and cattle.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11432056

• Wildfire smoke and female fertility: a big-picture, multi-study effort

  Aims to understand how wildfire smoke affects women’s fertility, using data from fertility clinics, a patient biorepository, and lab studies.

  NIH research Emory University · Atlanta, United States · NIH-11423672

• Long-term study of how pesticide exposure affects fertility and hormones from adolescence to young adulthood

  This study follows people in Ecuador from adolescence into their twenties to see how pesticide exposure may influence fertility and hormone health.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11419583

• Family Dynamics, Fertility, and Investments in Children Across Generations

  A long-running national survey will collect new data on families’ dynamics, fertility, and child outcomes to help understand how families grow and invest in children over generations.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11413524

• How CatSper and sperm health are controlled to help fertilization

  This NIH grant explores how factors like pH, temperature, polyamines, and hormones keep the sperm’s CatSper channel calm until the right moment to fertilize an egg, with the goal of understanding and improving fertility.

  NIH research Washington University · Saint Louis, United States · NIH-11391862

• How changes in reproductive policies affect fertility, maternal health, and baby health

  This project looks at whether recent state policies about reproductive and pregnancy care are linked to changes in who gets pregnant and how mothers and babies do across different communities.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11377185

• Understanding how piRNA guide proteins work to keep germ cells healthy across generations

  A research project looks at how small RNA guides influence gene regulation in germ cells and fertility, using C. elegans and other animals as models to shed light on human reproductive biology.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11366388

• How the gene TCERG1 may help protect fertility as organisms age

  Researchers are looking at whether the gene TCERG1 helps protect fertility and affects reproductive aging in animals and humans.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11362995

• Impact of reproductive policy changes on fertility and maternal/infant health

  This study looks at how new state policies on reproduction and pregnancy affect fertility, maternal health, and infant outcomes in the U.S.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11362589

• How air pollution may affect getting pregnant and early pregnancy loss

  This project looks at whether outdoor and indoor air pollution makes it harder for couples to get pregnant or raises the chance of miscarriage.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11362054

• Epigenetic control of retrotransposons and male fertility in mice

  This project looks at how male fertility in mice is tied to the way their genome keeps retrotransposons in check through epigenetic changes.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11357674

• Guiding fertility choices for girls at risk of POI from genetic conditions

  This project tests simple blood tests in young girls to predict whether they will have ovarian function later, helping families decide on fertility preservation options.

  NIH research Emory University · Atlanta, United States · NIH-11356286

• Support for young adult cancer survivors to manage care costs and preserve fertility

  This project adapts an online tool and provider training to help adolescent and young adult cancer survivors handle medical costs and find fertility‑preservation options.

  NIH research Washington University · Saint Louis, United States · NIH-11348332

• Exploring how male-derived RNAs in semen may affect fertility

  A study in fruit flies will look at whether RNAs from male semen influence female reproductive biology and fertility.

  NIH research University of Arizona · Tucson, United States · NIH-11336358

• AMH hormone to change ovarian function and fertility

  Researchers will give extra anti-Müllerian hormone (AMH) to non-human primates to learn whether it can safely change ovarian activity and fertility for possible use in women's reproductive care.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11330593

• Reproductive tract microbes and immune signals in couples' fertility

  This project looks at whether the microbes and immune signals in both partners' reproductive tracts are linked to IVF pregnancy success.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11323097

• Regulation of TRPM7 in eggs and early embryos to support fertility treatments

  Scientists are studying how the TRPM7 protein helps control essential minerals in eggs and early embryos to improve fertility and assisted reproductive technologies.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11319933

• How rare genetic-code patterns affect male fertility and reproductive behavior

  This work looks at how uncommon patterns in the genetic code can change protein production in sperm and reproductive brain cells and what that might mean for people with male infertility.

  NIH research Duke University · Durham, United States · NIH-11312662

• How insurance rules about fertility preservation affect costs and use of FP for young people with cancer

  This project looks at how state insurance mandates for fertility preservation impact what families pay and how often services are used by children, teens, and young adults facing cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11306493

• AYA Fertility Preservation Costs: Understanding Options for Young Cancer Survivors

  Young cancer survivors face tough choices about preserving fertility, and this project looks at how much different options cost so families can plan better.

  NIH research Washington University · Saint Louis, United States · NIH-11290931

• How the CatSper channel controls sperm movement and fertility

  This research looks at how a sperm protein called CatSper makes calcium signals that power sperm movement and could help men with fertility problems.

  NIH research Yale University · New Haven, United States · NIH-11284091

• How uterine sugar stores and obesity affect fertility

  This project looks at whether sugar stored in the uterine lining helps embryos survive and how obesity changes that for people trying to get pregnant.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11283952

• Chibby proteins and sperm development in male fertility

  Researchers are looking at how Chibby proteins affect sperm development and fertility in men with sperm problems.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11263736

• How family life, pregnancy choices, and parenting shape children's futures

  Researchers are collecting long-term survey information from U.S. families and their children to learn how family relationships, pregnancy decisions, and parenting affect children's lives over generations.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11262293

• How a protein called UCHL1 helps ovarian health and fertility

  Researchers are looking at whether the protein UCHL1 helps keep eggs healthy and protects fertility in people with ovaries.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11262277

• Fertility care access for cancer survivors

  This project looks at who can get fertility-preserving treatments and assisted reproductive care after cancer and whether broader access helps survivors have children.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11248793

• 19-year follow-up: pesticide exposure and fertility in young adults

  This follow-up looks at people who grew up near flower farms to learn how pesticide exposure relates to fertility and hormone health in their early adult years.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11228338

• Nemp1's role in egg quality and female fertility

  This work looks at how the protein Nemp1 supports healthy egg development and ovarian reserve in females, using mouse models to learn what may affect human fertility.

  NIH research Washington University · Saint Louis, United States · NIH-11224044

• Testing new contraceptive methods and their effects on fertility and early embryonic development.

  This study is working on creating new, safe, and affordable birth control options that can help prevent pregnancy by affecting ovulation and sperm function, so people can have more choices when it comes to contraception.

  NIH research Sri International · Menlo Park, United States · NIH-11202280

Related topics

Quick answers

How many Fertility clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in France (3 trials), Belgium (2 trials), Italy (2 trials), Sweden (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 2/3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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