Surgical options to preserve ovaries when treating endometriomas

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional study will enroll women aged 18–43 with at least one endometrioma larger than 20 mm who intend to conceive after surgery. Participants are randomly assigned to one of several surgical approaches — cystectomy, plasma vaporization, or sclerotherapy — performed at Clinique Tivoli in Bordeaux. Researchers will track pregnancies (natural and with fertility treatment), births continuing beyond 12 weeks, recurrence of endometriomas, surgical complications, and changes in pain using follow-up visits at about 3 months and 24 months after the procedure. The primary outcome is pregnancy within 24 months, with secondary outcomes including birth rates, recurrence, complications, and pain scores.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient aged between 18 and 43 years (inclusive)
* Patient diagnosed with endometriosis (by histology or imaging) and symptomatic, requiring surgery (pelvic pain and/or infertility and/or risk to an organ)
* Pelvic MRI or ultrasound performed within the last year showing at least one endometrioma larger than 20 mm in diameter
* Patient with an intention to conceive (probable or certain) after surgery
* Patient informed and having signed the consent form
* Patient covered by a social security scheme

Exclusion Criteria:

* Intraoperative finding that the cyst is not an endometrioma
* Patient under guardianship, conservatorship, or incapable of giving consent
* Patient without sufficient understanding of the French language
* Patient under judicial protection measures
* Patient who is pregnant or breastfeeding

Where it's running

• IFEMEndo - Clinique Tivoli
  Bordeaux, France Recruiting

Study contacts

• Principal investigator: Adrien CRESTANI — IFEMEndo - Clinique Tivoli
• Study coordinator: Clotilde HUET
• Email: recherche@ifemendo.fr
• Phone: +33 7 85 30 63 45

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.