Improving egg freezing techniques for fertility treatments
Official title: Validation of Semi-automatic Oocyte Vitrification by the GAVI® Machine in Medically Assisted Reproduction With Oocyte Donation
Run by University Hospital, Clermont-Ferrand · NCT06238570 · Data updated 2026-11-12
This study is testing a new way to freeze donor eggs to see if it helps them survive better and leads to more successful pregnancies when used in fertility treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 38 Years |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Status | Recruiting |
| Started | January 23, 2024 |
| Main results expected | September 2026 |
| Study ends | December 2026 |
| Registry record updated | April 30, 2026 |
| Trial ID | NCT06238570 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women who are egg donors with a good quality ovarian reserve and meet specific health criteria.
✕Probably not a fit
Patients who are pregnant, lactating, or unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of a semi-automated vitrification method for freezing donor oocytes compared to traditional manual techniques. The research aims to assess the survival rates of oocytes after warming and their subsequent fertilization success using intracytoplasmic sperm injection (ICSI). By utilizing closed devices for storage, the study seeks to minimize variability and improve the consistency of oocyte preservation. The outcomes will include the quality of embryos developed from vitrified oocytes and their potential for successful pregnancies in assisted reproductive technology.
Why it matters
Potential benefit: If successful, this study could enhance the success rates of fertility treatments by improving the preservation of donor oocytes.
How similar studies have gone: Previous studies have shown promising results with automated vitrification techniques, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Egg donor * Oocyte puncture for donation * Good quality ovarian reserve (Antral follicle count evaluated by ultrasound: CFA ≥ 7) * Negative serology status (HIV, hepatitis B and C, syphilis, CMV and HTLV) * Absence of symptoms or COVID contact * Absence of genetic contraindication to egg donation * Woman able to give informed consent to participate in research * Woman affiliated to a social security scheme Exclusion Criteria: * Decline to participate * Pregnant and lactating woman * Person under guardianship, curatorship, deprivation of liberty, protection of justice
Where it's running
-
CHU de Clermont-Ferrand
Clermont-Ferrand, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.