Guiding fertility choices for girls at risk of POI from genetic conditions
Official title: Informing Decision Making for Fertility Preservation in Genetic Conditions Associated with Primary Ovarian Insufficiency
Funded at Emory University · NIH-11356286 · Data updated 2026-11-12
This project tests simple blood tests in young girls to predict whether they will have ovarian function later, helping families decide on fertility preservation options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2026 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $444,067 |
| NIH project number | 1R21HD121948-01 |
| Project ID | NIH-11356286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Girls with high risk of POI due to genetic conditions such as Turner syndrome or classic galactosemia, assessed before puberty.
✕Less likely to help
Girls without high POI risk or those already beyond the prepubertal window may not benefit.
What this research studies
Premature ovarian insufficiency (POI) can threaten future fertility, especially in girls with Turner syndrome or classic galactosemia. This study looks at biomarkers like AMH and FSH in prepubertal girls to predict whether their ovaries will function before puberty. The researchers will collect data and analyze how early hormone levels relate to later ovarian reserve, aiming to inform timing and choice of fertility preservation. The work is conducted at Emory University and could guide clinical decisions for families facing POI risk.
Why it matters
Potential benefit: If successful, the findings could help families choose the most appropriate fertility preservation strategy sooner.
How similar studies have gone: Previous research has explored AMH and FSH as predictors in adults; this study extends prepubertal insights, with mixed prior success.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Fridovich-Keil, Judith L. — Emory University
- Study coordinator: Fridovich-Keil, Judith L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.