Condition

Crohn Disease (CD) clinical trials and research

• 54Clinical trials
• 1New in 30 days
• 21Countries

Newest Crohn Disease (CD) clinical trials

All recruiting trials (54)

• Reduce ultra-processed foods to help kids with Crohn's stay in remission longer

  This study tests whether and how reducing ultra-processed foods with dietitian guidance helps children and teens with Crohn's disease stay in remission longer.

  Recruiting University Hospital, Motol · Prague and 1 other locations · NCT07884045

• Endoscopic stricturotomy vs balloon dilation for small bowel Crohn’s stricture

  This trial tests whether endoscopic stricturotomy can be safely and effectively used to treat small bowel fibrotic strictures in Crohn’s disease, compared with endoscopic balloon dilation.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07833332

• Prediction of postoperative recurrence in Crohn's disease after surgery

  A multicenter study will test a multimodal model to predict which Crohn's patients are likely to have disease recur after intestinal resection.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07824791

• Perianal fistula imaging comparison using TPUS, MRI, EUS, and EUA

  This study tests how well four imaging methods—transperineal ultrasound, MRI, endoscopic ultrasound, and examination under anesthesia—detect and describe perianal fistulas in adults with Crohn's disease or unknown cause.

  Recruiting Asian Institute of Gastroenterology, India · Hyderabad, Telanagana · NCT07794410

• Familial IBD Early Risk

  This study tests whether clinical, environmental, and immune factors in first-degree relatives of people with Crohn’s disease or ulcerative colitis can predict who will develop IBD.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT07791862

• Impact of sucralose on gut health in Crohn's disease

  This study tests whether the non-nutritive sweetener sucralose changes gut bacteria in adults with Crohn's disease compared to healthy controls.

  Recruiting at 3 sites University Hospitals Cleveland Medical Center · Chagrin Falls, Ohio and 2 other locations · NCT07769437

• Characterization of Colorectal Dysplastic Lesions and Changes in Risk in IBD Patients

  This study tests how colorectal dysplastic lesions in adults with Crohn disease or ulcerative colitis change over time to help tailor screening and treatment.

  Recruiting at 2 sites Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Amiens and 1 other locations · NCT07719426

• Postoperative biologic therapy in Crohn's disease: which agent works best to prevent recurrence after surgery?

  This study looks back at adults with Crohn's disease to see if different biologic medicines given after ileocecal or other bowel surgery help prevent endoscopic recurrence within a year.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT07694674

• Biomarker Discovery and Validation Platform for Inflammatory Bowel Disease

  Researchers are testing biomarker models to see if they can measure and predict inflammation and treatment response in people with Crohn's disease, ulcerative colitis, or related IBD.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT07686406

• Autologous tSVF Injection for Refractory Perianal Crohn’s Disease

  We’re testing whether injecting a patient’s own mechanically processed tissue stromal vascular fraction around and into fistula tracts can help heal complex perianal Crohn’s disease in people who have not responded to standard therapies.

  Recruiting at 2 sites Asian Institute of Gastroenterology, India · Hyderabad, Telangana and 1 other locations · NCT07652632

• Impact of Advanced Crohn's Therapies on Sleep Quality

  In adults with Crohn's disease, this study tests whether starting advanced therapies changes sleep quality, using a Fitbit and sleep diaries to track patterns over about six months.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv · NCT07649408

• Wearable data to spot IBD flareups in people with ulcerative colitis or Crohn's disease

  This study tests whether heart‑rate variability from participants’ own wearables can help predict IBD flares.

  Recruiting at 2 sites Maastricht University Medical Center · 's-Hertogenbosch and 2 other locations · NCT07647640

• Individualizing Anti-TNF Therapy in IBD

  This study tests whether genetic markers can predict which anti-TNF–naïve IBD patients will respond to their first anti-TNF treatment.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv · NCT07644117

• Cryopreserved autologous SVF plus micrograft for refractory ano-perineal fistulas in Crohn's disease

  This trial tests whether thawed stromal vascular fraction (SVF) injected around fistulas can help Crohn’s patients who haven’t responded to prior therapy.

  Recruiting Phase 1/2 Assistance Publique Hopitaux De Marseille · Marseille · NCT07629245

• DB-3Q for Medically Refractory Crohn's Disease (bone marrow MSC–derived extracellular vesicles)

  A study tests DB-3Q, a stem cell–derived treatment given to adults with Crohn's disease that hasn’t fully responded to standard therapies.

  Recruiting Phase 2 Direct Biologics, LLC · St Louis, Missouri · NCT07625293

• LRG levels and IBD activity in European patients

  This study will test whether Leucine-rich α2-glycoprotein (LRG) levels reflect disease activity in adults with Crohn’s or ulcerative colitis who are undergoing routine endoscopy in Europe.

  Recruiting Imelda GI Clinical Research Center · Bonheiden · NCT07621783

• Guselkumab in Crohn's Disease: Optimising Care for Real-World Patients (OPTIM Study A)

  This study tests whether guselkumab can help adults with Crohn's disease, including those who have had prior therapies or partial responses, when used in real-world clinical settings.

  Recruiting Phase 4 Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Amiens · NCT07616687

• TNFi plus low-dose upadacitinib versus TNFi dose intensification for Crohn's disease with suboptimal response

  This trial tests whether adding low-dose upadacitinib to a standard TNF blocker helps adults with moderate-to-severe Crohn's disease who haven't responded well to standard-dose infliximab or adalimumab, compared with increasing the TNFi dose.

  Recruiting Phase 4 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07510191

• Does distending the intestine change how we see Crohn's activity on MRI?

  This study tests whether adding an intestinal distensionagent before MRI changes the measurement of Crohn's inflammation in adults with ileal or colonic disease.

  Recruiting University Hospital, Clermont-Ferrand · Amiens and 1 other locations · NCT07471438

• Measuring muscle strength and size in people with inflammatory bowel disease.

  This project will test whether ultrasound measurements of selected muscles, together with handgrip strength, can serve as a practical alternative to CT-based muscle measurements for adults with inflammatory bowel disease.

  Recruiting Sakarya University · Sakarya, Adapazarı · NCT07441447

• See if inflammation and scarring in Crohn's can be mapped from resected tissue

  This study tests whether detailed ex vivo MRI and tissue measurements on Crohn’s tissue removed during surgery can reveal inflammation versus fibrosis to guide future treatments.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT07413653

• Epigenetic‑guided versus usual care selection of vedolizumab or ustekinumab for adults with Crohn's disease

  This trial tests whether a blood epigenetic test that recommends either vedolizumab or ustekinumab helps adults with active Crohn's disease get better results than usual doctor-guided selection.

  Recruiting at 40 sites Alimentiv Inc. · Antwerp and 50 other locations · NCT07363044

• CEDUR — German inflammatory bowel disease registry

  This registry collects real-world health and treatment information from adults with Crohn's disease, ulcerative colitis, or indeterminate colitis in Germany to see how care, effectiveness, safety, and costs play out in routine practice.

  Recruiting ImmunoRegister gUG · Hamburg · NCT07319442

• See if relatives of Crohn's patients are at risk for developing Crohn's disease

  This study tests a risk score using blood biomarkers and lifestyle factors in first-degree relatives of people with Crohn's disease to see if it can predict who will develop the condition.

  Recruiting at 10 sites GLSMED Learning Health S.A. · Roma and 9 other locations · NCT07316621

• Infliximab plus the Crohn's Disease Exclusion Diet for children with Crohn's disease

  This will test whether starting a Crohn's Disease Exclusion Diet at the same time as infliximab helps children with moderate-to-severe Crohn's disease get better and stay in remission.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07314606

• Reducing ustekinumab dosing for Crohn's disease and ulcerative colitis

  This will try giving ustekinumab less often—changing from every 4 or 8 weeks to every 8 or 12 weeks—to see if people with Crohn's disease or ulcerative colitis in deep remission can stay well.

  Recruiting Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07303686

• Mirikizumab for Crohn's Disease: See if it helps heal the bowel walls

  This trial tests whether mirikizumab can help patients with Crohn's disease achieve transmural healing.

  Recruiting at 5 sites Phase 4 Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Brest and 7 other locations · NCT07292012

• Butyricum probiotic to help with Crohn’s disease with stricturing

  This study tests whether Clostridium butyricum, taken for two months before a colonoscopy, helps patients with Crohn’s disease and narrowing of the bowel.

  Recruiting Phase 1/2 San Giovanni Addolorata Hospital · Roma · NCT07263880

• Long-term effectiveness and safety of fecal microbiota transplantation

  This project will follow about 4,000 people who have had fecal microbiota transplantation to see if it helps keep them in remission and is safe over 3 months, 1 year, and 5 years for conditions like recurrent C. difficile, IBD, IBS, and chronic constipation.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT07261826

• Switching to guselkumab for adults with active IBD after ustekinumab

  We will try guselkumab (Tremfya) in adults with active IBD whose symptoms didn't improve enough on ustekinumab.

  Recruiting at 12 sites TIDHI Innovation Inc. · Calgary, Alberta and 13 other locations · NCT07245394

• Laparoscopic right colectomy with extended mesenteric excision and Kono-S anastomosis for Crohn's of the terminal ileum

  This will test whether combining laparoscopic right colectomy with extended mesenteric excision and the Kono-S anastomosis helps people with terminal ileum Crohn's by lowering complications and recurrence.

  Recruiting Tzaneio General Hospital · Piraeus, Attica · NCT07231601

• Reducing ultra-processed foods in children and teens with IBD

  This project will test whether short nutrition handouts or handouts plus a brief video can help children and teens with IBD eat fewer ultra-processed foods.

  Recruiting Connecticut Children's Medical Center · Hartford, Connecticut · NCT07224113

• SMART-IBD app for teens with inflammatory bowel disease

  This will test whether the SMART-IBD smartphone app helps adolescents ages 13–17 with IBD take their medicines and manage symptoms better than completing daily diaries alone.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07195123

• Artificial-intelligence versus standard review to detect Crohn's disease on video capsule endoscopy

  This trial will test whether AI-assisted video capsule endoscopy can find small-bowel Crohn's disease and shorten reading time in adults with suspected Crohn's after a non-diagnostic ileocolonoscopy.

  Recruiting Fondazione Poliambulanza Istituto Ospedaliero · Brescia, Brescia · NCT07111715

• Using intestinal ultrasound to predict vedolizumab response and transmural healing in early Crohn's disease

  This project will test if intestinal ultrasound can predict how well vedolizumab works and show transmural healing in adults with early Crohn's disease.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07093294

• HB-adMSCs treatment for Crohn's disease

  This trial will try intravenous HB-adMSCs versus placebo to see if they improve symptoms in adults 18–65 with Crohn's disease.

  Recruiting Phase 2 Hope Biosciences Research Foundation · Sugar Land, Texas · NCT07077746

• Switching adults with Crohn's disease from Stelara (ustekinumab) to the biosimilar Uzpruvo

  This will see if adults with stable Crohn's disease who switch from Stelara® to the biosimilar Uzpruvo® stay on the biosimilar and remain well over 12 months.

  Recruiting at 10 sites EG Labo · Amiens and 10 other locations · NCT07077681

• TIDHI Healing Circuits mental health program for people with IBD

  This study tests whether Healing Circuits™ delivered by a social worker or via a self-guided online program helps adults with IBD who have moderate anxiety or depression.

  Recruiting TIDHI Innovation Inc. · North York, Ontario · NCT07013578

• Tirzepatide to heal small-bowel Crohn's disease after failure of advanced therapies

  This trial will test whether tirzepatide can help heal ileal or ileocolonic Crohn's disease in adults whose inflammation has not responded to at least two advanced treatments.

  Recruiting at 2 sites Phase 2 Washington University School of Medicine · Beverly Hills, California and 2 other locations · NCT06976853

• Using early fecal calprotectin to prevent Crohn's disease return after intestinal surgery

  This trial tests whether measuring fecal calprotectin early after bowel surgery and intensifying ustekinumab when levels rise can prevent Crohn's disease from coming back in adults at higher risk.

  Recruiting University Hospital, Clermont-Ferrand · Amiens and 7 other locations · NCT06972901

• Hybrid stricturotomy plus balloon dilation versus stricturotomy alone for short Crohn's strictures

  This study will test whether adding balloon dilation to endoscopic stricturotomy helps adults with short Crohn's strictures have fewer symptoms and need fewer repeat procedures or surgery.

  Recruiting Asian Institute of Gastroenterology, India · Hyderabad, Telangana · NCT06958159

• Preventing Crohn's disease recurrence after surgery with EXL01

  This study is testing if a new oral medication called EXL01 can help prevent Crohn's disease from coming back after surgery in people who have just had an operation for it.

  Recruiting at 12 sites Phase 2 Saint-Louis Hospital, Paris, France · Clermont-Ferrand and 11 other locations · NCT06925061

• Combining Ustekinumab with Semi-Enteral Nutrition for Crohn's Disease Before Surgery

  This study is testing if combining a medication called Ustekinumab with a special diet can help adults with Crohn's Disease feel better and get healthier before surgery.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06912815

• Adding the Crohn's Disease Exclusion Diet to anti-TNF treatment for Crohn's disease and ulcerative colitis

  This will test whether adding the Crohn's Disease Exclusion Diet to anti‑TNF medicines helps adults with active Crohn's disease or ulcerative colitis.

  Recruiting IRCCS Ospedale San Raffaele · Milan, Michigan · NCT06896305

• Exploring the link between diet and immune-related diseases in families

  This study is trying to see how the diets of families with members who have conditions like Juvenile Idiopathic Arthritis, Crohn's Disease, or Ulcerative Colitis affect their health and treatment options.

  Recruiting at 4 sites Meyer Children's Hospital IRCCS · Florence, Italy and 3 other locations · NCT06862843

• AI-enhanced MRE to detect bowel fibrosis in Crohn's disease

  This project will test whether an AI program applied to magnetic resonance enterography (MRE) scans can accurately identify and characterize bowel wall fibrosis in adults with Crohn's disease who are scheduled for bowel resection.

  Recruiting at 2 sites First Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong and 4 other locations · NCT06858553

• Assessing the reliability of intestinal ultrasound in Crohn's disease

  This study is testing if a special ultrasound can help doctors check how active Crohn's disease is in patients and see if different doctors agree on the results.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06833450

• Optimizing Infliximab Treatment for Inflammatory Bowel Disease

  This study is testing a new way to give infliximab to adults with moderate-to-severe inflammatory bowel disease who haven't improved with steroids, to see if personalized dosing can help them feel better.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago · NCT06758024

• Assessing gut microbiome's role in predicting inflammatory bowel disease progression

  This study is trying to see if the types of bacteria in the gut can help predict how inflammatory bowel diseases like Crohn's disease and ulcerative colitis will progress in the first year after diagnosis.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago · NCT06756100

• Oral glycan supplementation to modify the gut lining and reduce Crohn's recurrence after ileal surgery

  This trial will test whether an oral glycan supplement can change interactions between gut bacteria and the mucosal immune system to prevent Crohn's disease recurrence in adults after ileal or ileocecal resection.

  Recruiting GLSMED Learning Health S.A. · Lisbon, Lisbon District · NCT06727253

• Investigating the effects of a blueberry-rich diet on colitis

  This study is testing if eating a diet high in blueberries can help people with ulcerative colitis and Crohn's disease feel better by improving their gut health and reducing inflammation.

  Recruiting Universität Duisburg-Essen · Bamberg, Bavaria · NCT06698601

• Comparing water versus polyethylene glycol for bowel preparation before MRE in Crohn's disease

  This study will test whether drinking water works as well as polyethylene glycol to distend the small bowel before an MRE for adults with Crohn's disease.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06690632

• Fluorescence imaging of a drug for inflammatory bowel disease

  This study is testing a special version of a drug for inflammatory bowel disease to see how well it targets the right areas in the body and to find the best dose for patients.

  Recruiting Phase 1/2 University Medical Center Groningen · Groningen · NCT06606808

• Observational cohort for early spondyloarthritis in Germany

  This study is tracking patients with early spondyloarthritis in Germany to see how the disease progresses and affects their quality of life over time.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT01277419

Related topics

Quick answers

How many Crohn Disease (CD) clinical trials are recruiting right now?

54, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in France (11 trials), China (9 trials), United States (7 trials), Italy (6 trials), Netherlands (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 4: 4, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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