Exploring the link between diet and immune-related diseases in families
Official title: Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
Run by Meyer Children's Hospital IRCCS · NCT06862843 · Data updated 2026-11-12
This study is trying to see how the diets of families with members who have conditions like Juvenile Idiopathic Arthritis, Crohn's Disease, or Ulcerative Colitis affect their health and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Meyer Children's Hospital IRCCS Academic / other |
| Locations | 4 sites (Florence, Italy and 3 other locations) |
| Status | Recruiting |
| Started | February 7, 2024 |
| Main results expected | May 15, 2025 |
| Study ends | November 15, 2025 |
| Registry record updated | March 6, 2025 |
| Trial ID | NCT06862843 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include families with children aged 0-18 years, where at least one child or adult is affected by IBD or JIA.
✕Probably not a fit
Patients with monogenic diseases, ileostomies, or colectomies, as well as those with chronic inflammatory bowel diseases or autoimmune diseases, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the relationship between dietary habits and 'omic' profiles in families with at least one member affected by chronic immune-mediated inflammatory conditions, specifically Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD), and Ulcerative Colitis (UC). By collecting questionnaires and biological samples, the study seeks to understand how diet influences the development and management of these inflammatory diseases. It builds on previous research that highlighted the connection between diet, gut microbiome, and health outcomes, potentially paving the way for dietary interventions in treatment strategies.
Why it matters
Potential benefit: If successful, this study could lead to new dietary recommendations that help manage or prevent chronic inflammatory conditions in affected individuals.
How similar studies have gone: Previous studies have shown promising results in understanding the impact of diet on inflammatory conditions, suggesting that this approach is both relevant and potentially beneficial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: For families with at least one child/adult affected by IBD/JIA: * Father and mother with children aged between 0-18 years, in good health. * At least one adult or one child affected by IBD, or a child affected by JIA, regardless of ongoing therapy and without distinction of disease severity or activity. For healthy families: \- Father and mother with children aged between 0-18 years, in good health and not affected by chronic inflammatory bowel diseases or chronic autoimmune inflammatory diseases in general. Exclusion Criteria: For subjects affected by IBD: * Monogenic disease * Children with an ileostomy or who have undergone a colectomy For subjects affected by JIA: \- No exclusion criteria For healthy subjects: \- Any chronic inflammatory bowel disease, autoimmune disease, or ongoing infectious diseases.
Where it's running
-
AOU Meyer IRCCS
Florence, Italy, Italy Recruiting -
Università La Sapienza di Roma
Roma, Roma, Italy Recruiting -
Università di Foggia
Foggia, Italy Recruiting -
Ospedale Villa Sofia Cervello, Università di Palermo
Palermo, Italy Recruiting
Study contacts
- Study coordinator: Paolo Lionetti, MD, PhD, Ordinary Professor
- Email: paolo.lionetti@unifi.it
- Phone: +39 3398416059
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Familial IBD Early Risk
This study tests whether clinical, environmental, and immune factors in first-degree relatives of people with Crohn’s disease or ulcerative colitis can predict who will develop IBD.
-
Biomarker Discovery and Validation Platform for Inflammatory Bowel Disease
Researchers are testing biomarker models to see if they can measure and predict inflammation and treatment response in people with Crohn's disease, ulcerative colitis, or related IBD.
-
Wearable data to spot IBD flareups in people with ulcerative colitis or Crohn's disease
This study tests whether heart‑rate variability from participants’ own wearables can help predict IBD flares.
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Individualizing Anti-TNF Therapy in IBD
This study tests whether genetic markers can predict which anti-TNF–naïve IBD patients will respond to their first anti-TNF treatment.
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LRG levels and IBD activity in European patients
This study will test whether Leucine-rich α2-glycoprotein (LRG) levels reflect disease activity in adults with Crohn’s or ulcerative colitis who are undergoing routine endoscopy in Europe.
-
CEDUR — German inflammatory bowel disease registry
This registry collects real-world health and treatment information from adults with Crohn's disease, ulcerative colitis, or indeterminate colitis in Germany to see how care, effectiveness, safety, and costs play out in routine practice.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.