Characterization of Colorectal Dysplastic Lesions and Changes in Risk in IBD Patients
Official title: Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study
Run by Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · NCT07719426 · Data updated 2026-11-12
This study tests how colorectal dysplastic lesions in adults with Crohn disease or ulcerative colitis change over time to help tailor screening and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Academic / other |
| Locations | 2 sites (Amiens and 1 other locations) |
| Status | Recruiting |
| Started | September 17, 2026 |
| Main results expected | September 17, 2033 |
| Study ends | September 17, 2033 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT07719426 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with diagnosed Crohn disease or ulcerative colitis who require screening colonoscopy for dysplasia and meet the specified disease and extent criteria.
✕Probably not a fit
Patients with ileal Crohn disease or rectal ulcerative colitis, or those undergoing therapeutic endoscopy without prior or ongoing follow-up at a participating center, may not benefit from study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multicenter observational study focusing on IBD patients who require colonoscopy for dysplasia. It aims to characterize dysplastic lesions and stratify evolving colorectal cancer risk in Crohn disease and ulcerative colitis. The study collects endoscopic and clinical data to understand patterns of lesion development, persistence, and recurrence after endoscopic management. No intervention is specified within the protocol; data collection will inform future risk stratification and management strategies. The findings could support more personalized surveillance approaches for IBD-associated dysplasia.
Why it matters
Potential benefit: If successful, the study could improve risk stratification and guide personalized colonoscopy intervals and management for IBD patients with dysplasia.
How similar studies have gone: Prior work suggests evolving endoscopic techniques and closer surveillance can reduce progression risk, but this specific observational characterization of evolving dysplasia risk in IBD is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients age ≥ 18 years * Documented diagnosis of CD or UC established based on standard clinical, endoscopic and histological criteria. * IBD patients requiring screening colonoscopy for dysplasia as following: * IBD (CD/UC) evolving for more than 8 years, or for ≥1 year if associated with Primary Sclerosing Cholangitis (PSC) * For UC: Extended ulcerative colitis (E2 or E3 in the Montreal classification) * For CD: Colonic (L2) or ileocolonic (L3) Crohn's disease with \> 50% involvement of the colon. * Patient affiliated to the health security system * Patient who has received information about the study by the investigator and agreed to participate. Exclusion Criteria: * Patient followed for ileal Crohn's disease (L1) * Patient followed for rectal ulcerative colitis (E1) * Patient referred for a therapeutic endoscopic procedure, without prior or subsequent follow-up in the participating center * Patients \< 18 years old * Patient under guardianship or curatorship * Patient objects to their personal data being used in the context of research
Where it's running
-
CHU d'Amiens
Amiens, France Recruiting -
CHU de Besançon
Besançon, France Recruiting
Study contacts
- Study coordinator: SEGUIN A Project manager
- Email: aseguin@getaid.org
- Phone: + 33 (0) 7 66 42 69 85
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.