Measuring muscle strength and size in people with inflammatory bowel disease.
Evaluation of Sarcopenia in Patients With Inflammatory Bowel Disease
This project will test whether ultrasound measurements of selected muscles, together with handgrip strength, can serve as a practical alternative to CT-based muscle measurements for adults with inflammatory bowel disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sakarya University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Sakarya, Adapazarı) |
| Trial ID | NCT07441447 on ClinicalTrials.gov |
What this trial studies
This prospective, single-center observational project enrolls adults with confirmed IBD to measure muscle strength and muscle mass using handgrip dynamometry and targeted muscle ultrasonography. Selected muscles (rectus femoris, vastus intermedius, gastrocnemius medialis, biceps brachii, rectus abdominis, and internal oblique) will be measured for thickness and cross-sectional area by ultrasound. For participants with an abdominal CT within the previous six months, L3 skeletal muscle cross-sectional area will be measured from archived images to compare with ultrasound results. The primary outcome is the correlation and agreement between ultrasound-based measures and CT-derived L3 muscle area.
Who should consider this trial
Good fit: Adults (≥18 years) with a confirmed diagnosis of IBD who can provide informed consent, undergo handgrip testing and muscle ultrasound, and have an abdominal CT performed within the previous six months are ideal candidates.
Not a fit: Patients with known neuromuscular disorders, major orthopedic limitations affecting strength testing, abdominal wall defects, pregnancy, or incomplete clinical or imaging data are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, ultrasound could offer a fast, radiation-free, and more accessible way to monitor muscle mass in patients with IBD.
How similar studies have performed: Ultrasound has shown promising agreement with CT for muscle measurement in other patient groups, but validation specifically in IBD populations remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Established diagnosis of inflammatory bowel disease (ICD-10: K50.\* Crohn's disease, K51.\* ulcerative colitis) * Ability to provide written informed consent * Ability to undergo ultrasonographic muscle assessment and handgrip strength testing * Availability of an abdominal computed tomography (CT) scan performed within the previous 6 months Exclusion Criteria: * Known neuromuscular disorders or primary muscle diseases * Major orthopedic conditions affecting muscle strength assessment * Pregnancy * Abdominal wall defects or conditions interfering with ultrasound assessment * Incomplete clinical or imaging data * Any condition preventing reliable ultrasound or handgrip measurement
Where this trial is running
Sakarya, Adapazarı
- Sakarya University Faculty of Medicine, Training and Research Hospital — Sakarya, Adapazarı, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Yunus Günegül
- Email: yunusgunegul@sakarya.edu.tr
- Phone: +905386046017
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.