Reduce ultra-processed foods to help kids with Crohn's stay in remission longer
Official title: Impact of Ultra-Processed Food Reduction on Remission Duration in Paediatric Patients With Crohn's Disease
Run by University Hospital, Motol · NCT07884045 · Data updated 2026-11-12
This study tests whether and how reducing ultra-processed foods with dietitian guidance helps children and teens with Crohn's disease stay in remission longer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 10 Years to 18 Years |
| Sex | All |
| Enrollment | 124 (estimated) |
| Sponsor | University Hospital, Motol Academic / other |
| Locations | 2 sites (Prague and 1 other locations) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT07884045 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children and adolescents aged 10 to 18 with Crohn's disease in clinical remission for at least 3 months and no major dietary restrictions that would exclude participation.
✕Probably not a fit
Patients with Crohn's disease who do not respond to dietary changes or who have factors limiting remission duration may not experience a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will compare a counseling program focused on lowering ultra-processed food intake with standard healthy-eating advice in pediatric Crohn's patients in clinical remission. Participants aged 10-18 will be randomized to receive regular dietitian-led guidance to increase minimally processed foods versus usual dietary guidance, alongside their standard medical care. The trial will assess remission duration, safety and nutritional adequacy, growth, and overall quality of the diet. The intervention emphasizes gradual, sustainable changes and avoidance of major dietary restrictions. Outcomes will inform whether dietary modification can complement pharmacologic therapy to maintain remission in pediatric Crohn's disease.
Why it matters
Potential benefit: If successful, participants may experience longer remission periods and improved nutritional health through a sustainable, less ultra-processed diet.
How similar studies have gone: Prior nutrition-focused studies suggest diet can influence Crohn's activity, but this randomized trial assesses ultra-processed food reduction specifically in pediatrics, a relatively novel approach for remission maintenance.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children and adolescents aged 10 to 18 years (inclusive). * Diagnosis of Crohn's disease. * Clinical remission (MINI score \<8) maintained for at least 3 months before randomization. * Ability of the participant and parent/legal guardian to provide informed consent/assent according to local regulations. Exclusion Criteria: * Stoma or previous colectomy. * Pregnancy. * Exclusive enteral nutrition (EEN), Crohn's Disease Exclusion Diet (CDED), Healthy \& Tasty diet, parenteral nutrition, or other major self-imposed dietary restrictions (including vegan or vegetarian diets) at the start of the intervention. - Partial enteral nutrition and self-modified partial CDED or Healthy \& Tasty diets are permitted. * Eating disorder. * Change in Crohn's disease therapy without prior achievement of clinical remission (MINI score \<8).
Where it's running
-
University Hospital Motol and Homolka
Prague, Czechia Recruiting -
Department of Paediatric Gastroenterology, University Hospital Motol and Homolka
Prague, Czechia Not yet recruiting
Study contacts
- Study coordinator: Tereza Lerchova, MD, Ph.D.
- Email: terezadrskova@gmail.com
- Phone: +420 775 201 573
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.