New gene therapy to save limbs from severe blood flow issues

Who could benefit from this research

What this research studies

This research focuses on developing a novel gene therapy aimed at treating critical limb ischemia (CLI), a severe condition characterized by poor blood flow to the legs, leading to pain, non-healing wounds, and potentially amputation. The approach involves using gene therapy to promote the growth of new blood vessels in affected limbs, thereby improving blood flow and healing. The study seeks to identify effective gene delivery methods and transgenes that can enhance the body's natural healing processes by attracting stem and progenitor cells to the ischemic tissue. This innovative therapy aims to provide a solution for patients who do not respond to standard treatments.

Why it matters

Where this research is happening

• University of Miami School of Medicine
  Coral Gables, United States Active

Researchers

• Principal investigator: Velazquez, Omaida C — University of Miami School of Medicine
• Study coordinator: Velazquez, Omaida C

Related research

Other NIH-funded projects on the same topics.

• Ultrasound-activated implants to restore blood flow in severe leg ischemia

  This project develops ultrasound-triggered implants that release blood-vessel–growing proteins to help people with critical limb ischemia regain circulation.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11241145

• New gene therapy to improve blood flow and prevent limb amputation in patients with severe artery blockage

  This study is testing a new gene therapy that aims to help people with critical limb ischemia by encouraging blood vessel growth in their legs, which could help heal wounds and reduce the need for amputations, especially for those who haven't had success with regular treatments.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11175713

• Investigating the role of a specific microRNA in improving blood flow in diabetic patients with critical limb ischemia

  This study is looking at how a tiny molecule called miR-130b can help improve blood flow in the legs of people with diabetes who have serious circulation problems, with the goal of finding new ways to prevent amputations and help patients feel better.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10989897

• Investigating treatment outcomes for patients with critical limb ischemia and end-stage renal disease

  This study is looking at the best treatment options for people with critical limb ischemia who also have severe kidney disease, to help doctors and patients make better choices about care and improve health outcomes.

  NIH research University of Florida · Gainesville, United States · NIH-10897869

• Understanding how diabetes affects blood vessel fat metabolism to reduce surgical complications

  This study is looking at how diabetes affects blood flow and can lead to serious problems like amputations, and it will test if a medication called Fenofibrate, which helps lower fat levels in the blood, can help reduce the risk of these complications for people with diabetes.

  NIH research Washington University · Saint Louis, United States · NIH-10810711

• Exploring pain management and psychological factors in critical limb ischemia

  This study is looking at how different ways to manage pain and mental health support can help people with critical limb ischemia (CLI) feel better and improve their quality of life.

  NIH research Yale University · New Haven, United States · NIH-10599675

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.