New gene therapy to save limbs from severe blood flow issues
Novel Gene Therapy for Critical Limb Ischemia and Limb Salvage in Vascular Occlusive Disease
This study is testing a new gene therapy to help people with critical limb ischemia, a serious condition that causes poor blood flow to the legs, by encouraging the growth of new blood vessels to improve healing and reduce pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10843923 on NIH RePORTER |
What this research studies
This research focuses on developing a novel gene therapy aimed at treating critical limb ischemia (CLI), a severe condition characterized by poor blood flow to the legs, leading to pain, non-healing wounds, and potentially amputation. The approach involves using gene therapy to promote the growth of new blood vessels in affected limbs, thereby improving blood flow and healing. The study seeks to identify effective gene delivery methods and transgenes that can enhance the body's natural healing processes by attracting stem and progenitor cells to the ischemic tissue. This innovative therapy aims to provide a solution for patients who do not respond to standard treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with critical limb ischemia who have not responded to conventional therapies.
Not a fit: Patients with mild peripheral arterial disease or those who are not experiencing severe symptoms of limb ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the need for amputations in patients suffering from critical limb ischemia.
How similar studies have performed: While previous gene therapy approaches for CLI have faced challenges, this research aims to explore new methods and has the potential to build on past findings.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Velazquez, Omaida C — University of Miami School of Medicine
- Study coordinator: Velazquez, Omaida C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.