Using FAZA PET/MRI to assess critical limb ischemia before and after revascularization

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the use of a novel imaging tool, FAZA PET/MRI, to assess patients with critical limb ischemia (CLI) before and after they undergo revascularization treatment. The study aims to determine the location and degree of tissue hypoxia in the extremities, which is crucial for understanding the effectiveness of the endovascular therapy. By utilizing this advanced imaging technique, the trial seeks to improve diagnostic capabilities and patient outcomes in those suffering from CLI. Participants will be monitored for changes in their condition as a result of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>= 18 years;
* Patients with clinical evidence of critical limb ischemia that are candidates for revascularization treatment;
* A negative urine or serum pregnancy test in women of child-bearing age;
* Ability to provide written informed consent to participate in the study.

Exclusion Criteria:

* Contraindication for MR as per current institutional guidelines;
* Inability to lie supine for at least 30 minutes;
* Pregnant or breastfeeding;
* Unable or unwilling to provide informed consent;
* Impending amputation within 6 weeks of presentation;
* Previous metallic hardware in the lower limbs;
* Unable to have ethanol.

Where it's running

• University Health Network
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Patrick Veit-Haibach, MD — University Health Network, Toronto
• Study coordinator: Patrick Veit-Haibach, MD
• Email: Patrick.Veit-Haibach@uhn.ca
• Phone: 416-340-4800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.