New gene therapy to improve blood flow and prevent limb amputation in patients with severe artery blockage
Novel Gene Therapy for Critical Limb Ischemia and Limb Salvage in Vascular Occlusive Disease
This study is testing a new gene therapy that aims to help people with critical limb ischemia by encouraging blood vessel growth in their legs, which could help heal wounds and reduce the need for amputations, especially for those who haven't had success with regular treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11175713 on NIH RePORTER |
What this research studies
This research focuses on developing a novel gene therapy aimed at treating critical limb ischemia (CLI), a severe condition caused by poor blood flow to the legs. The therapy seeks to enhance blood vessel growth in ischemic limbs, potentially allowing for healing of non-healing wounds and reducing the need for amputations. The approach involves using advanced gene delivery systems to activate the body's natural healing processes and recruit stem cells to the affected areas. Patients who do not respond to standard treatments may find this innovative therapy particularly beneficial.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with critical limb ischemia who have not responded to conventional therapies.
Not a fit: Patients with mild peripheral arterial disease or those who have not yet developed critical limb ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the number of major limb amputations and improve the quality of life for patients suffering from critical limb ischemia.
How similar studies have performed: While previous gene therapy approaches for CLI have faced challenges, this research aims to explore new methods and has the potential to build on past findings to achieve better outcomes.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Velazquez, Omaida C — University of Miami School of Medicine
- Study coordinator: Velazquez, Omaida C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.