Investigating the role of a specific microRNA in improving blood flow in diabetic patients with critical limb ischemia

Who could benefit from this research

What this research studies

This research focuses on understanding how a specific microRNA, miR-130b, affects blood vessel formation (angiogenesis) in patients with diabetes who suffer from critical limb ischemia (CLI). The study aims to identify the mechanisms by which miR-130b can enhance blood flow to the lower extremities, which is often compromised in diabetic patients. By analyzing blood samples and conducting experiments on cells, researchers hope to uncover new therapeutic targets that could improve limb perfusion and reduce the risk of amputation. The approach includes both laboratory studies and potential clinical applications to directly benefit patients.

Why it matters

Where this research is happening

• Brigham and Women's Hospital
  Boston, United States Active

Researchers

• Principal investigator: Feinberg, Mark W — Brigham and Women's Hospital
• Study coordinator: Feinberg, Mark W

Related research

Other NIH-funded projects on the same topics.

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• Investigating treatment outcomes for patients with critical limb ischemia and end-stage renal disease

  This study is looking at the best treatment options for people with critical limb ischemia who also have severe kidney disease, to help doctors and patients make better choices about care and improve health outcomes.

  NIH research University of Florida · Gainesville, United States · NIH-10897869

• New gene therapy to save limbs from severe blood flow issues

  This study is testing a new gene therapy to help people with critical limb ischemia, a serious condition that causes poor blood flow to the legs, by encouraging the growth of new blood vessels to improve healing and reduce pain.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10843923

• Understanding how diabetes affects blood vessel fat metabolism to reduce surgical complications

  This study is looking at how diabetes affects blood flow and can lead to serious problems like amputations, and it will test if a medication called Fenofibrate, which helps lower fat levels in the blood, can help reduce the risk of these complications for people with diabetes.

  NIH research Washington University · Saint Louis, United States · NIH-10810711

• Exploring pain management and psychological factors in critical limb ischemia

  This study is looking at how different ways to manage pain and mental health support can help people with critical limb ischemia (CLI) feel better and improve their quality of life.

  NIH research Yale University · New Haven, United States · NIH-10599675

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.