Investigating the role of a specific microRNA in improving blood flow in diabetic patients with critical limb ischemia
miR-130b, angiogenesis, and diabetic critical limb ischemia
This study is looking at how a tiny molecule called miR-130b can help improve blood flow in the legs of people with diabetes who have serious circulation problems, with the goal of finding new ways to prevent amputations and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10989897 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific microRNA, miR-130b, affects blood vessel formation (angiogenesis) in patients with diabetes who suffer from critical limb ischemia (CLI). The study aims to identify the mechanisms by which miR-130b can enhance blood flow to the lower extremities, which is often compromised in diabetic patients. By analyzing blood samples and conducting experiments on cells, researchers hope to uncover new therapeutic targets that could improve limb perfusion and reduce the risk of amputation. The approach includes both laboratory studies and potential clinical applications to directly benefit patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are diabetic patients experiencing critical limb ischemia or severe peripheral artery disease.
Not a fit: Patients without diabetes or those not experiencing critical limb ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve blood flow and reduce the risk of amputation for diabetic patients with critical limb ischemia.
How similar studies have performed: Previous research has shown promising results in using microRNAs for therapeutic purposes, indicating potential success for this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Feinberg, Mark W — Brigham and Women's Hospital
- Study coordinator: Feinberg, Mark W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.