Examining microRNAs in patients with Critical Limb Ischemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study enrolls 40 patients suffering from critical limb ischemia (CLI) to analyze the expression of microRNAs in skeletal muscle biopsies. Patients will be categorized based on the severity of their condition, with some undergoing bypass surgery and others facing major amputations. The results will be compared to a control group of 40 patients with infrarenal abdominal aortic aneurysm who do not have CLI. The study aims to identify and validate specific microRNAs that may play a role in CLI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Cases:

* patients affected by CLI candidates for popliteal exploration surgery and/or subgenual femoropopliteal bypass.
* Patients affected by CLI with irreversible ischemia and/or distal gangrene of the lower limb candidates for major amputation of the lower limb.

Controls:

• patients affected by infrarenal abdominal aortic aneurysm (AAA) undergoing endovascular exclusion surgery of the AAA (EVAR) who are free from CLI, affected and not affected by type 2 diabetes mellitus.

Exclusion Criteria:

* Pregnant women
* Patients carriers of genetic diseases
* Patients suffering from malignant neoplasia

Where it's running

• Irccs Policlinico San Donato
  San Donato Milanese, Milan, Italy Recruiting

Study contacts

• Principal investigator: Fabio Martelli — IRCCS Policlinico S. Donato
• Study coordinator: Fabio Dr Martelli
• Email: fabio.martelli@grupposandonato.it
• Phone: +39 0226437762

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.