Understanding how diabetes affects blood vessel fat metabolism to reduce surgical complications
Official title: Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical Complications
Funded at Washington University · NIH-10810711 · Data updated 2026-11-12
This study is looking at how diabetes affects blood flow and can lead to serious problems like amputations, and it will test if a medication called Fenofibrate, which helps lower fat levels in the blood, can help reduce the risk of these complications for people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $514,989 |
| NIH project number | 5R01HL153262-04 |
| Project ID | NIH-10810711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with diabetes who are at risk of developing critical limb ischemia or require surgical intervention for peripheral arterial disease.
✕Less likely to help
Patients without diabetes or those who do not have peripheral arterial disease may not benefit from this research.
What this research studies
This research investigates the relationship between diabetes and peripheral arterial disease (PAD), focusing on how lipid metabolism in blood vessels can lead to severe complications like critical limb ischemia and amputations. The study aims to explore the effects of Fenofibrate, a medication that lowers triglycerides, on lipid metabolism and its potential to reduce amputation rates in diabetic patients. By examining the mechanisms behind Fenofibrate's benefits, the research seeks to improve treatment strategies for patients at risk of surgical complications due to diabetes. Patients may be involved in clinical assessments to better understand their condition and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that significantly reduce the risk of amputations in diabetic patients with peripheral arterial disease.
How similar studies have gone: Previous research has shown that medications like Fenofibrate can reduce amputation rates in diabetic patients, indicating a promising avenue for further exploration.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Zayed, Mohamed a. — Washington University
- Study coordinator: Zayed, Mohamed a.
Related research
Other NIH-funded projects on the same topics.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Retinal signals in early diabetes and how they affect vision
This grant looks at how diabetes changes the signals in the retina that control vision, with a focus on inner retinal cells and how these changes may lead to vision problems.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Bringing WHO HEARTS-D diabetes care into Bangladesh cities
A program to help urban clinics in Bangladesh adopt WHO HEARTS-D guidelines to improve detection, treatment, and control of type 2 diabetes.
-
AI-powered fundus imaging to screen for type 2 diabetes
A mobile AI tool uses eye images to help screen adults for type 2 diabetes in clinics or communities.
-
AI-powered eye imaging to screen for type 2 diabetes with a mobile phone
A plan to use AI on smartphone retinal images to help spot type 2 diabetes early, especially in people who may not have easy access to care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.