Understanding how diabetes affects blood vessel fat metabolism to reduce surgical complications
Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical Complications
This study is looking at how diabetes affects blood flow and can lead to serious problems like amputations, and it will test if a medication called Fenofibrate, which helps lower fat levels in the blood, can help reduce the risk of these complications for people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10810711 on NIH RePORTER |
What this research studies
This research investigates the relationship between diabetes and peripheral arterial disease (PAD), focusing on how lipid metabolism in blood vessels can lead to severe complications like critical limb ischemia and amputations. The study aims to explore the effects of Fenofibrate, a medication that lowers triglycerides, on lipid metabolism and its potential to reduce amputation rates in diabetic patients. By examining the mechanisms behind Fenofibrate's benefits, the research seeks to improve treatment strategies for patients at risk of surgical complications due to diabetes. Patients may be involved in clinical assessments to better understand their condition and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with diabetes who are at risk of developing critical limb ischemia or require surgical intervention for peripheral arterial disease.
Not a fit: Patients without diabetes or those who do not have peripheral arterial disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that significantly reduce the risk of amputations in diabetic patients with peripheral arterial disease.
How similar studies have performed: Previous research has shown that medications like Fenofibrate can reduce amputation rates in diabetic patients, indicating a promising avenue for further exploration.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Zayed, Mohamed a. — Washington University
- Study coordinator: Zayed, Mohamed a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.