Local and systemic macrophage activation in coronary and peripheral artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses Optical Coherence Tomography to assess macrophage presence and activation in both coronary and peripheral atherosclerotic lesions. It aims to compare intraplaque macrophages with circulating monocyte subpopulations and understand how these patterns relate across different vascular beds. Participants include adults with chronic coronary disease, non-ST elevation ACS, chronic claudication, and critical limb ischemia. Exclusion criteria cover major organ dysfunction, autoimmune conditions, recent infection, and recent surgeries to reduce confounding factors. The lead site is Maria Cecilia Hospital, Cotignola, with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with chronic coronary artery disease;
* Patients with no-ST elevation acute coronary syndrome;
* Patients with chronic claudication (Rutherford II-III)
* Patients with critical limb ischemia (Rutherford IV-V).

Exclusion Criteria:

* Severe renal dysfunction
* Severe valve disease
* Advanced heart failure
* Advanced liver disease
* Chronic inflammatory or autoimmune disease
* Use of antinflammatory drugs
* Acute infection
* Recent surgical procedures

Where it's running

• Maria Cecilia Hospital
  Cotignola, Ravenna, Italy Recruiting

Study contacts

• Study coordinator: Roberto Nerla, MD, PhD
• Email: robertonerla83@gmail.com
• Phone: +390545217032

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.