Analyzing Inflammatory Biomarkers for Diagnosing CNS Autoimmune Diseases
Evaluation of a Combined Analysis of Serum and Cerebrospinal Fluid Inflammatory Biomarkers to Help in Etiological Diagnosis of Central Nervous System Autoimmune Diseases
This study is testing if certain markers in blood and spinal fluid can help doctors more accurately diagnose multiple sclerosis and other similar brain conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Trial ID | NCT05056740 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve the diagnostic process for central nervous system diseases, particularly multiple sclerosis (MS), by analyzing inflammatory biomarkers in serum and cerebrospinal fluid (CSF). The study focuses on identifying specific cytokines and free light chains that could differentiate MS from other similar conditions. Patients referred for diagnostic work-ups of white matter lesions will have their blood and CSF analyzed to establish potential biomarkers for more accurate diagnoses. The goal is to enhance diagnostic accuracy and reduce the complexity of the diagnostic process for suspected MS cases.
Who should consider this trial
Good fit: Ideal candidates include patients referred for diagnostic evaluations of white matter lesions who are undergoing routine blood and CSF analyses.
Not a fit: Patients with contraindications to spinal taps or MRIs will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses for patients with suspected CNS autoimmune diseases.
How similar studies have performed: Other studies have shown promise in using inflammatory biomarkers for diagnosing CNS diseases, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients referred to our center for the diagnostic work-up of White Matter Lesions * Patients that need a routine blood analysis * Patients that need a routine CSF analysis * Non opposition to research consent Exclusion Criteria: * Patients with a contraindication to perform spinal tap (increase bleeding risk medicine or disease) * Patients with a contraindication to MRI (metal prosthesis...)
Where this trial is running
Nice
- Centre Hospitalier Universitaire de Nice — Nice, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.