Using virtual and mixed reality technology with mirror therapy for stroke rehabilitation
Official title: Technology-based and Activity-based Design of Mirror Therapy Principles: Two Mixed Reality and Virtual Reality Mirrored-hand Systems for Stroke Rehabilitation
Run by Chang Gung Memorial Hospital · NCT05903235 · Data updated 2026-11-12
This study is testing new virtual and mixed reality therapies combined with mirror therapy to see if they can help stroke patients recover their movement better than traditional methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Taoyuan City) |
| Status | Recruiting |
| Started | March 13, 2024 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | October 22, 2026 |
| Trial ID | NCT05903235 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 20 to 80 who have experienced a unilateral stroke and have a specific range of motor function as measured by the Fugl-Meyer Assessment.
✕Probably not a fit
Patients with global or receptive aphasia, severe neglect, or significant comorbidities that affect therapy participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop and test virtual reality (VR) and mixed reality (MR) systems combined with mirror therapy (MT) for stroke rehabilitation. Initially, a feasibility study will assess user experiences with these new systems among stroke patients. Following this, a randomized controlled trial will compare the effectiveness of VR+MT and MR+MT against traditional MT in improving motor functions. The study will also identify which patients respond best to these innovative therapies based on their initial motor abilities and mental imagery skills.
Why it matters
Potential benefit: If successful, this approach could enhance rehabilitation outcomes for stroke patients by providing more effective therapy options.
How similar studies have gone: While the use of VR and MR in rehabilitation is gaining interest, this specific combination with mirror therapy is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Phase Ⅰ: Design and Development of the VR+MT and MR+MT Systems \& Feasibility Study Inclusion Criteria: * diagnosed with unilateral stroke * age of 20 to 80 years * a baseline Fugl-Meyer Assessment of the Upper Extremity score of 20 to 60 * able to follow the study instructions and provide the feedback of user experiences verbally Exclusion Criteria: * diagnosed with global or receptive aphasia * the presence of severe neglect * the existence of major medical problems or comorbidities that could interfere with upper-limb usage and pain, or disrupt visual or auditory perception Phase Ⅱ: Validation and Comparison of Clinical Treatment Efficacy Inclusion Criteria: * diagnosed with unilateral stroke * more than 6 months after stroke onset * age of 20 to 80 years * a baseline Fugl-Meyer Assessment of the Upper Extremity score of 20 to 60 * able to follow the study instructions * capable of participating in the assessment process and treatment program Exclusion Criteria: * diagnosed with global or receptive aphasia * the presence of severe neglect * the existence of major medical problems or comorbidities that could interfere with upper-limb usage and pain, or disrupt visual or auditory perception
Where it's running
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Taoyuan Chang Gung Memorial Hospital
Taoyuan City, Taiwan Recruiting
Study contacts
- Principal investigator: Yu-Wei Hsieh, PhD — Department of Occupational Therapy, College of Medicine, Chang Gung University
- Study coordinator: Yu-Wei Hsieh, PhD
- Email: ywhsieh@mail.cgu.edu.tw
- Phone: +886-3-2118800
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.