The role of gut bacteria in heart and metabolic diseases
Official title: Gut Microbiota and Cardiometabolic Diseases
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10653038 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut can affect heart health and metabolism, and it's for anyone interested in understanding how these tiny organisms might help improve conditions like heart disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $2,425,292 |
| NIH project number | 5P01HL147823-05 |
| Project ID | NIH-10653038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals with cardiovascular diseases or metabolic disorders who are interested in understanding the role of gut health in their conditions.
✕Less likely to help
Patients without cardiovascular or metabolic diseases may not receive direct benefits from this research.
What this research studies
This research investigates how gut microbiota influences cardiovascular and metabolic diseases. It aims to understand the mechanisms by which gut bacteria produce metabolites that affect heart health and metabolic functions. The study involves analyzing gut microbial pathways and their impact on conditions like atherosclerosis through both animal models and human participants. By exploring these connections, the research seeks to uncover new therapeutic targets for improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and metabolic conditions by targeting gut microbiota.
How similar studies have gone: Other research has shown promising results in understanding the gut microbiome's role in health, indicating potential for success in this area.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Hazen, Stanley L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Hazen, Stanley L
Related research
Other NIH-funded projects on the same topics.
-
Gut microbiome and heart/metabolic disease influence
A large NIH grant is exploring how gut bacteria affect common heart and metabolic diseases and how we might use that knowledge to improve health.
-
Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression
A multi-year study will look at gut bacteria and related markers in people with Parkinson’s disease to understand how the gut-brain connection may influence symptoms and progression.
-
Gut-Brain Axis in Parkinson’s Disease: biomarkers and procedures to track progression
A patient-focused program to study how gut health and the brain interact in Parkinson’s disease using biomarkers and clinical procedures.
-
Vitamin D, gut bacteria and dementia risk in older adults with HIV
This work will look at whether low vitamin D and changes in gut bacteria are linked to higher dementia risk in older adults living with chronic HIV and similar community members.
-
Gut bacteria and lung immune cells shape viral lung infections
A study explores how gut microbes affect lung immune cells and severity of respiratory viral infections to identify potential ways to reduce illness.
-
Gut bacteria and Tuft-2 cells linked to early colorectal cancer risk in young Black Americans
This grant aims to understand how gut microbes and Tuft-2 cells may predict aggressive colon adenomas in young Black adults who develop colorectal cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.