Genotype-guided approach to improve cardiometabolic health using natriuretic peptides

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of natriuretic peptides (NPs) in regulating cardiometabolic health, particularly in individuals with genetically lower NP levels. It focuses on understanding how exercise and glucose challenges affect NP responses in adults who carry a specific genetic variant associated with lower NP levels. The study aims to explore the metabolic benefits of NPs and their potential to mitigate risks associated with cardiovascular diseases and diabetes. Participants will undergo dietary assessments, exercise capacity evaluations, and challenges to assess their metabolic responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults: Age more than or equal to 18; an equal number of Males and Females
* Consent to the collection of genetic material
* Willing to adhere to the study protocol

Exclusion Criteria:

* Age \<18, at screening.
* BMI \>45 kg/m2.
* Blood pressure more than 140/90 mmHg.
* Participants who are taking more than 2 hypertension medications.
* History of diabetes or fasting plasma glucose \>126 mg/dl or HbA1C\>=6.5% or prior treatment with antidiabetic medication.
* Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia)
* Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence);
* Estimated GFR \< 60 ml/min/1.73 m2; albumin creatinine ratio ≥30 mg/g
* Hepatic Transaminase (AST and ALT) levels \>3x the upper limit of normal
* Anemia (men, Hct \< 38%; women, Hct \<36%)
* Inability to exercise on a treadmill

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Pankaj Arora, MD, FAHA — University of Alabama at Birmingham
• Study coordinator: Nehal Vekariya, MS
• Email: nvekariya@uabmc.edu
• Phone: 205-934-7173

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.