Investigating how oxalate metabolism affects heart and liver diseases
Official title: Dysregulated Oxalate Metabolism in Cardiometabolic Diseases
Funded at Louisiana State Univ Hsc Shreveport · NIH-11095882 · Data updated 2026-11-12
This study is looking at how the way your body processes oxalate might be connected to nonalcoholic fatty liver disease and heart problems, and it hopes to find new ways to help improve your health by understanding these links better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | August 5, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $428,730 |
| NIH project number | 5R01DK136685-03 |
| Project ID | NIH-11095882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with nonalcoholic fatty liver disease or atherosclerotic cardiovascular disease.
✕Less likely to help
Patients without these specific liver or cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of oxalate metabolism in patients with nonalcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (CVD). It aims to identify the metabolic pathways linking these two conditions, particularly how dysregulated oxalate production may contribute to disease severity. By studying liver cells and using advanced techniques like transcriptomics, the research seeks to uncover potential therapeutic targets to improve patient outcomes. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from both liver and cardiovascular diseases.
How similar studies have gone: While the specific focus on oxalate metabolism in this context is novel, related research has shown promise in understanding metabolic pathways in liver and cardiovascular diseases.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Rom, Oren Shalom — Louisiana State Univ Hsc Shreveport
- Study coordinator: Rom, Oren Shalom
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.