Understanding genetic risks for heart and metabolic diseases in diverse populations
Leveraging pleiotropy to develop polygenic risk scores for cardiometabolic diseases
['FUNDING_R03'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10924035
This study is looking at how our genes might affect the risk of heart disease and type 2 diabetes, especially in people from different backgrounds, to help create better ways to predict and prevent these conditions for everyone.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10924035 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that contribute to cardiometabolic diseases, such as type 2 diabetes and heart disease, particularly in populations with non-European ancestry. By analyzing genetic data from the All of Us research program, the study aims to identify genetic variants that influence multiple health conditions simultaneously, a phenomenon known as pleiotropy. The goal is to develop more accurate polygenic risk scores that can predict disease risk in diverse populations, ultimately leading to better-targeted prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals of African ancestry who are at risk for or have been diagnosed with cardiometabolic diseases.
Not a fit: Patients of non-African ancestry may not benefit directly from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and personalized prevention strategies for cardiometabolic diseases in diverse populations.
How similar studies have performed: Previous research has shown promise in using genetic insights to improve disease risk prediction, making this approach both innovative and grounded in emerging scientific evidence.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ADEBAMOWO, SALLY NNEOMA — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: ADEBAMOWO, SALLY NNEOMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus