Real-world cardiometabolic protection outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, historical prospective cohort uses clinical records from the First Affiliated Hospital of Sun Yat-sen University to follow adults diagnosed with cardiometabolic conditions. Eligible patients are those aged 18 or older with diagnoses such as hypertension, diabetes, overweight/obesity, dyslipidemia, or hyperuricemia based on standard clinical criteria. The primary outcomes are all-cause death and cardiovascular death, and the secondary outcome is major adverse cardiovascular events (MACE). The study will measure associations between established or suspected cardiometabolic risk factors and these outcomes in a real-world representative cohort.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years old;
* Patients with clinical diagnosis of metabolic cardiovascular disease, including hypertension, diabetes, obesity, dyslipidemia, hyperuricemia.

  1. Hypertension and normal high blood pressure: Three standardized blood pressure measurements in the clinic on different days, and all the blood pressure values of the three measurements were systolic blood pressure ≥ 120 mmHg and/or diastolic blood pressure ≥ 80 mmHg;
  2. Diabetes: ① Typical symptoms of diabetes, and any of the following: ② Random blood glucose ≥ 11.1 mmol/L; ③ Fasting blood glucose (FPG) ≥ 7.0 mmol/L; ④ OGTT 2-hour postprandial blood glucose ≥ 11.1 mmol/L; ⑤ HbA1c ≥ 6.5%;
  3. Obesity and overweight: Body mass index (BMI) ≥ 24 kg/m²;
  4. Dyslipidemia: At least one of the following lipid indicators is abnormal: ① Total cholesterol (TC) ≥ 6.2 mmol/L; ② Low-density lipoprotein cholesterol (LDL-C) ≥ 4.1 mmol/L; ③ High-density lipoprotein cholesterol (HDL-C) \< 1.0 mmol/L; ④ Triglyceride (TG) ≥ 2.3 mmol/L; ⑤ Lipoprotein(a) ≥ 30 mg/dL;
  5. Hyperuricemia: The fasting blood uric acid levels on two different days were \> 420 μmol/L (7 mg/dL) in men and \> 360 μmol/L (6 mg/dL) in women.

Exclusion Criteria:

* Patients unable to provide informed consent.

Where it's running

• The First Affiliated Hospital of Sun Yat-sen Univerity
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Xiaodong Zhuang
• Email: zhuangxd3@mail.sysu.edu.cn
• Phone: +8613760755035

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.