Gut microbiome and heart/metabolic disease influence
Official title: Gut Microbiota and Cardiometabolic Diseases
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11335422 · Data updated 2026-11-12
A large NIH grant is exploring how gut bacteria affect common heart and metabolic diseases and how we might use that knowledge to improve health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2019 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,421,237 |
| NIH project number | 2P01HL147823-06A1 |
| Project ID | NIH-11335422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with or at risk for atherosclerotic cardiovascular disease or related metabolic conditions.
✕Less likely to help
Patients without cardiovascular risk factors or not involved in microbiome-related research may not directly benefit.
What this research studies
This program studies how gut microbes influence cardiovascular and metabolic health using animal models to understand disease pathways and how microbial enzymes and metabolites may drive atherosclerosis and thrombosis. The team is testing whether targeting gut microbial pathways could modulate disease in living systems and examining potential drug approaches. The work is organized into three projects and supporting cores to integrate data, biology, and methods. The effort aims to translate findings toward better prevention and treatment options for people with ASCVD and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new microbiome-based strategies to prevent or treat heart disease and metabolic disorders.
How similar studies have gone: Previous work has linked gut microbiota to cardiovascular phenotypes, with ongoing efforts to translate these findings into therapies.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Hazen, Stanley L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Hazen, Stanley L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.