Identifying subtypes and mechanisms of cardiometabolic diseases using multi-omics data
Leveraging multi-omics for endotyping to identify subtypes and mechanisms of cardiometabolic diseases
['FUNDING_CAREER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11080249
This study is looking at why some people who are obese don’t develop health problems related to their weight, and it’s for anyone interested in understanding how different factors like genes and proteins can affect their risk for heart and metabolic issues; by sharing some health information and samples, you can help researchers find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11080249 on ClinicalTrials.gov |
What this research studies
This research investigates the variability in cardiometabolic disease risk factors among patients, particularly focusing on why some obese individuals do not develop complications. By utilizing multi-omics data, including genetic, proteomic, and metabolomic information, the study aims to identify distinct subtypes of cardiometabolic diseases and the underlying mechanisms that contribute to these conditions. The approach involves clustering individuals based on their biological data to uncover novel determinants of disease and responses to treatments like bariatric surgery. Patients may be involved in providing biological samples and health data to help refine these insights.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults with obesity or other risk factors for cardiometabolic diseases, particularly those considering bariatric surgery.
Not a fit: Patients without obesity or those who do not have any risk factors for cardiometabolic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for cardiometabolic diseases, improving outcomes for patients.
How similar studies have performed: Previous research utilizing multi-omics approaches has shown promise in identifying disease subtypes and mechanisms, suggesting potential for success in this novel application.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAGHERI NARAGHI, MINOO SADAT — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: BAGHERI NARAGHI, MINOO SADAT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: atherosclerotic coronary disease