Identifying subtypes and mechanisms of cardiometabolic diseases using multi-omics data
Official title: Leveraging multi-omics for endotyping to identify subtypes and mechanisms of cardiometabolic diseases
Funded at Vanderbilt University Medical Center · NIH-11080249 · Data updated 2026-11-12
This study is looking at why some people who are obese don’t develop health problems related to their weight, and it’s for anyone interested in understanding how different factors like genes and proteins can affect their risk for heart and metabolic issues; by sharing some health information and samples, you can help researchers find new ways to treat these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $157,550 |
| NIH project number | 5K01HL165020-03 |
| Project ID | NIH-11080249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include adults with obesity or other risk factors for cardiometabolic diseases, particularly those considering bariatric surgery.
✕Less likely to help
Patients without obesity or those who do not have any risk factors for cardiometabolic diseases may not benefit from this research.
What this research studies
This research investigates the variability in cardiometabolic disease risk factors among patients, particularly focusing on why some obese individuals do not develop complications. By utilizing multi-omics data, including genetic, proteomic, and metabolomic information, the study aims to identify distinct subtypes of cardiometabolic diseases and the underlying mechanisms that contribute to these conditions. The approach involves clustering individuals based on their biological data to uncover novel determinants of disease and responses to treatments like bariatric surgery. Patients may be involved in providing biological samples and health data to help refine these insights.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for cardiometabolic diseases, improving outcomes for patients.
How similar studies have gone: Previous research utilizing multi-omics approaches has shown promise in identifying disease subtypes and mechanisms, suggesting potential for success in this novel application.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Bagheri Naraghi, Minoo Sadat — Vanderbilt University Medical Center
- Study coordinator: Bagheri Naraghi, Minoo Sadat
Related research
Other NIH-funded projects on the same topics.
-
Cardiometabolic Health in World Trade Center Responders and How Exposures Help Shape It
This project looks at how surviving the World Trade Center cleanup exposure might influence long-term heart and metabolic health in responders.
-
Food is Medicine programs to improve diet and reduce cardiometabolic diseases
A health study from Tufts University is testing how adding medically tailored meals and food-based prescriptions within healthcare can improve diet and lower cardiometabolic disease risk.
-
Tulane program to accelerate clinical research on heart and metabolic diseases
A funded program at Tulane supports teams researching heart and metabolic diseases to speed up translating discoveries into better patient care.
-
Gut microbiome and heart/metabolic disease influence
A large NIH grant is exploring how gut bacteria affect common heart and metabolic diseases and how we might use that knowledge to improve health.
-
Fat-linked amino acids and fatty liver with heart disease risk
This work looks at whether changes in fat-linked amino acids made in the liver are tied to fatty liver disease and a higher risk of clogged arteries.
-
Macrophage roles in heart disease and fat-related conditions
A multi-project program looks at how immune cells called macrophages contribute to heart disease, obesity, and fatty liver, with the aim of finding new ways to prevent and treat these conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.