How cholesterol regulation affects immune responses in heart diseases
Official title: Sterol regulation of immunometabolic responses in cardiometabolic diseases
Funded at Yale University · NIH-11029401 · Data updated 2026-11-12
This study is looking at how changes in cholesterol levels can affect the immune system and contribute to heart diseases like atherosclerosis, and it aims to find new ways to help improve heart health by understanding these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $787,267 |
| NIH project number | 1R01HL177553-01 |
| Project ID | NIH-11029401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with cardiometabolic diseases, particularly those with atherosclerosis.
✕Less likely to help
Patients who do not have any cardiovascular risk factors or existing heart conditions may not benefit from this research.
What this research studies
This research investigates the role of cholesterol regulation in the immune responses related to cardiometabolic diseases, particularly atherosclerosis. It focuses on how alterations in cholesterol levels can lead to chronic inflammation, which is a key factor in the progression of heart diseases. The study will explore genetic modifications in macrophages to understand their impact on cholesterol metabolism and inflammation. By examining these mechanisms, the research aims to identify potential therapeutic targets for improving cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and slow the progression of heart diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of cholesterol in immune responses, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Fernandez Hernando, Carlos — Yale University
- Study coordinator: Fernandez Hernando, Carlos
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.