Cardiometabolic Health in World Trade Center Responders and How Exposures Help Shape It
Official title: Cardiometabolic diseases in the World Trade Center general responder cohort and the role of subsequent environmental exposures
Funded at Icahn School of Medicine at Mount Sinai · NIH-11480112 · Data updated 2026-11-12
This project looks at how surviving the World Trade Center cleanup exposure might influence long-term heart and metabolic health in responders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 12, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2027 |
| Award (this year) | $462,502 |
| NIH project number | 5R01ES034864-05 |
| Project ID | NIH-11480112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Responders and others who were present during the 9/11 cleanup and who have ongoing health monitoring through the WTCHP may be good candidates.
✕Less likely to help
People without exposure to the WTC cleanup or without access to WTCHP data may not directly benefit.
What this research studies
The study uses data from the World Trade Center Health Program to follow more than 40,000 responders over time and see how past environmental exposures relate to risks like heart disease and diabetes. It will analyze medical exams, lab results, and questionnaires collected during two decades of follow-up to identify patterns in cardiometabolic risk after 9/11. By linking exposure history with health outcomes, the research aims to fill gaps in what we know beyond lung cancer and respiratory issues. The goal is to better understand who is at risk and why, so care and prevention can be tailored for affected individuals.
Why it matters
Potential benefit: If successful, results could lead to improved prevention, earlier detection, and better management of cardiometabolic diseases in WTC responders.
How similar studies have gone: Prior research has linked WTC exposures to respiratory and cancer outcomes; this study extends inquiry into cardiometabolic diseases with a large, well-characterized cohort.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Yitshak Sade, Maayan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Yitshak Sade, Maayan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.