Understanding Heart Disease in Type 1 Diabetes
Substance P Metabolites and Receptors in the Pathogenesis of Cardiac Disease in Type 1 Diabetes
This research explores new ways to protect the heart from damage in people with type 1 diabetes, focusing on natural body chemicals called Substance P.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-11194459 on NIH RePORTER |
What this research studies
Heart disease is a serious concern for people with type 1 diabetes, often leading to heart failure because the heart muscle changes and becomes stiff. Currently, there are no specific treatments to stop or reverse these heart changes. Our team is looking into how certain natural chemicals, called Substance P and its related molecules, might help protect the heart. We've seen promising results in animal models where replacing these chemicals helped prevent heart scarring and improved heart function. This work aims to uncover new treatment options to keep hearts healthier for those living with type 1 diabetes.
Who could benefit from this research
Good fit: This foundational research is for patients with type 1 diabetes who are at risk for or already experiencing heart complications.
Not a fit: Patients without type 1 diabetes or those with other forms of heart disease may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new medications that prevent or reverse heart damage in patients with type 1 diabetes.
How similar studies have performed: Previous work in animal models of type 2 diabetes has shown that replacing Substance P or using its mimetics can protect the heart from damage.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Levick, Scott P — West Virginia University
- Study coordinator: Levick, Scott P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.