Using fresh autologous blood transfusion after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of transfusing fresh autologous whole blood at the end of cardiopulmonary bypass during elective cardiac surgery. The study aims to reduce total blood loss 24 hours post-surgery and improve mitochondrial oxygen delivery, as indicated by plasma succinate levels. It is a prospective randomized interventional trial comparing fresh autologous blood transfusion to standard care for managing bleeding. The goal is to enhance patient outcomes by minimizing the need for stored blood products, which carry risks of complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult subjects aged 18 to 90
2. Able to provide informed consent
3. Willing to accept autologous or allogenic blood transfusion
4. Scheduled for elective cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

1. Pre-operative administration of allogenic blood bank products in the previous 3 months
2. Hemodynamically unstable defined as a systolic blood pressure less than 90 mmHg with a heart rate greater 100 or requiring intravenous vasopressor medications
3. Significant active infection or sepsis defined by positive blood culture or positive wound culture
4. Hemoglobin less than 7 g/dl

Where it's running

• University of Colorado Hospital
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Nathan Clendenen, M.D. — University of Colorado - School of Medicine
• Study coordinator: Nathan J Clendenen, M.D.
• Email: nathan.clendenen@cuanschutz.edu
• Phone: 720-848-6709

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.