Investigating how certain proteins affect heart disease in people with type 1 diabetes
Official title: Substance P Metabolites and Receptors in the Pathogenesis of Cardiac Disease in Type 1 Diabetes
Funded at West Virginia University · NIH-11074273 · Data updated 2026-11-12
This study is looking at how a protein called substance P might help protect the hearts of people with type 1 diabetes, and it hopes to find new ways to prevent or improve heart problems related to the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project start | September 18, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $712,748 |
| NIH project number | 1U01DK142329-01 |
| Project ID | NIH-11074273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are at risk for cardiovascular complications.
✕Less likely to help
Patients without type 1 diabetes or those who do not have cardiovascular issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of substance P and its metabolites in the development of heart disease among individuals with type 1 diabetes. The study uses animal models to explore how these proteins can protect against heart damage and improve heart function. By identifying new treatment approaches that target specific receptors involved in cardiac health, the research aims to find ways to prevent or reverse heart complications associated with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent heart disease in patients with type 1 diabetes.
How similar studies have gone: Previous research has shown promising results in using similar approaches to protect heart health in diabetes, indicating potential for success in this study.
Where this research is happening
-
West Virginia University
Morgantown, United States Active
Researchers
- Principal investigator: Levick, Scott P — West Virginia University
- Study coordinator: Levick, Scott P
Related research
Other NIH-funded projects on the same topics.
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Understanding Heart Disease in Type 1 Diabetes
This research explores new ways to protect the heart from damage in people with type 1 diabetes, focusing on natural body chemicals called Substance P.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
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A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
-
How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.