Measuring how the brain, autonomic system, and blood vessels interact

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The protocol collects simultaneous physiological signals related to cortical activity, autonomic function, and cerebrovascular autoregulation in adults undergoing major cardiac surgery and applies new multivariate, time-varying mathematical tools to characterize their interactions. Data will combine recordings such as EEG or other cortical measures, heart rhythm and variability, and cerebral blood flow or blood pressure dynamics to model cross-system links. The methods aim to identify patterns that connect brain and reflex function to heart and circulatory outcomes and to mood symptoms. Results will be used to propose integrated biomarkers that bridge physiological and psychological dimensions of depression and cardiac risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age older than 18 years
* spontaneous sinus rhythm
* signed informed consent
* indication to heart surgery

Exclusion Criteria:

* age lower than 18 years
* absence of sinus rhythm
* pregnancy
* impossibility of informed consent

Where it's running

• IRCCS Policlinico San Donato
  San Donato Milanese, Milan, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.