How diabetes affects gut bacteria and heart disease
Official title: Role of Diabetes Associated Intestinal Dysbiosis in cardiac disease
Funded at Georgia State University · NIH-10874429 · Data updated 2026-11-12
This study is looking at how changes in gut bacteria from diabetes might increase the risk of heart disease, even if blood sugar levels are normal, and it hopes to find new ways to help prevent heart problems for people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $521,855 |
| NIH project number | 5R01HL168465-02 |
| Project ID | NIH-10874429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk for heart disease.
✕Less likely to help
Patients without diabetes or those who do not have any cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates the relationship between gut bacteria changes caused by diabetes and the risk of heart disease. It aims to understand how these changes can lead to inflammation and heart dysfunction, even in the absence of high blood sugar levels. The study will involve characterizing specific gut bacteria that contribute to these issues and exploring how diabetes alters gut function. By manipulating gut microbiota, the research seeks to find new ways to prevent heart disease in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart disease in people with diabetes.
How similar studies have gone: Previous studies have shown a correlation between gut microbiota dysbiosis and increased risk of heart disease, suggesting that this research builds on established findings.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Zou, Jun — Georgia State University
- Study coordinator: Zou, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.